Caspase: Difference between revisions
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'''Caspase''' (CASP) are cysteine-aspartic proteases (see [[Protease]]) which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP.<br /> | '''Caspase''' (CASP) are cysteine-aspartic proteases (see [[Protease]]) which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP.<br /> | ||
* '''CASP-1''' (or '''Interleukin-1 beta converting enzyme, ICE''') cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. See [[Human Caspase-1]]<br /> | * '''CASP-1''' (or '''Interleukin-1 beta converting enzyme, ICE''') cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. See:<br /> | ||
* '''CASP-3''' or ('''Apopain; Cysteine protease CPP32''') interacts with CASP-8 and CASP-9 during cell apoptosis. See [[Sandox Bay Serrano]] | [[Human Caspase-1]]<br /> | ||
* '''CASP-6''' is involved in the activation of cascade of caspases during apoptosis. See [[Molecular Playground/Caspase-6 (new)]] | * '''CASP-3''' or ('''Apopain; Cysteine protease CPP32''') interacts with CASP-8 and CASP-9 during cell apoptosis. See:<br /> | ||
* '''CASP-7''' is a heterodimer consisting of P20 (human residues 1-198) and P11 (human residues 199-303) subunits. CASP-7 catalytic domain consists of residues 57-303. is an important initiator CASP and drICE is an effector of apoptosis CASP in ''Drosophila melanogaster''. See [[Molecular Playground/Caspase-7 Dynamics]] | [[Sandox Bay Serrano]]<br /> | ||
* '''CASP-9''' is an aspartic protease linked to mitochondrial death pathway. See [[Molecular Playground/Caspase-9 Regulation]].<br /> | [[Student Projects for UMass Chemistry 423 Spring 2012-5]]<br /> | ||
[[Caspase-3 Regulatory Mechanisms]]<br /> | |||
* '''CASP-6''' is involved in the activation of cascade of caspases during apoptosis. See:<br/> | |||
[[Molecular Playground/Caspase-6 (new)]]<br /> | |||
[[Caspase-6 and neurodegeneration]]<br /> | |||
* '''CASP-7''' is a heterodimer consisting of P20 (human residues 1-198) and P11 (human residues 199-303) subunits. CASP-7 catalytic domain consists of residues 57-303. is an important initiator CASP and drICE is an effector of apoptosis CASP in ''Drosophila melanogaster''. See:<br /> [[Molecular Playground/Caspase-7 Dynamics]]<br /> | |||
[[Molecular Playground/Executioner Caspase-7]]<br /> | |||
* '''CASP-9''' is an aspartic protease linked to mitochondrial death pathway. See:<br /> | |||
[[Molecular Playground/Caspase-9 Regulation]].<br /> | |||
* '''Metacaspase''' (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi. | * '''Metacaspase''' (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi. | ||
<ref>PMID:12920126</ref><ref>PMID:8035875</ref> | <ref>PMID:12920126</ref><ref>PMID:8035875</ref> | ||