Cytochrome c nitrite reductase: Difference between revisions

Revision as of 16:34, 13 January 2020

Function

Cytochrome c nitrite reductase or cytochrome c552 (ccNiR) catalyzes the reduction of nitrite to ammonia as one of the key steps in the nitrogen cycle where it participates in the anaerobic energy metabolism of dissimilatory nitrate ammonification^[1].

Structural highlights

Cytochrome c nitrite reductase with (PDB code 2e80). In the Wolinella succinogenes ccNiR structure the ^[2]. . Water molecules are shown as red spheres. Rare-earth element .

Cytochrome c nitrite reductase with 5 heme groups complex with NO2, acetate, Ca+2 ion (green) and Y+3 ion (cyan) (PDB code 2e80)

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3D structures of cytochrome c nitrite reductase3D structures of cytochrome c nitrite reductase

Updated on 13-January-2020

ReferencesReferences

↑ Einsle O, Messerschmidt A, Stach P, Bourenkov GP, Bartunik HD, Huber R, Kroneck PM. Structure of cytochrome c nitrite reductase. Nature. 1999 Jul 29;400(6743):476-80. PMID:10440380 doi:10.1038/22802
↑ Einsle O, Messerschmidt A, Huber R, Kroneck PM, Neese F. Mechanism of the six-electron reduction of nitrite to ammonia by cytochrome c nitrite reductase. J Am Chem Soc. 2002 Oct 2;124(39):11737-45. PMID:12296741

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Michal Harel, Alexander Berchansky

[1] Einsle O, Messerschmidt A, Stach P, Bourenkov GP, Bartunik HD, Huber R, Kroneck PM. Structure of cytochrome c nitrite reductase. Nature. 1999 Jul 29;400(6743):476-80. PMID:10440380 doi:10.1038/22802

[2] Einsle O, Messerschmidt A, Huber R, Kroneck PM, Neese F. Mechanism of the six-electron reduction of nitrite to ammonia by cytochrome c nitrite reductase. J Am Chem Soc. 2002 Oct 2;124(39):11737-45. PMID:12296741

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 == Structural highlights ==
-Cytochrome c nitrite reductase with <scene name='83/833267/Cv/5'>5 heme groups</scene> (PDB code [[2e80]]). In the ''Wolinella succinogenes'' ccNiR structure the <scene name='83/833267/Cv/2'>substrate NO2 binds to the Fe+3 atom of the heme group and makes hydrogen bonds to side chains of residues R114 and H277</scene><ref>PMID:12296741</ref>. <scene name='83/833267/Cv/4'>NO2 hydrogen bonds via water molecules</scene>. Water molecules are shown as red spheres. Rare-earth element <scene name='83/833267/Cv/6'>Yttrium ion binding site</scene>.
+Cytochrome c nitrite reductase with <scene name='83/833267/Cv/5'>5 heme groups</scene> (PDB code [[2e80]]). In the ''Wolinella succinogenes'' ccNiR structure the <scene name='83/833267/Cv/2'>substrate NO2 binds to the Fe+3 atom of the heme group and makes hydrogen bonds to side chains of residues R114 and H277</scene><ref>PMID:12296741</ref>. <scene name='83/833267/Cv/4'>NO2 hydrogen bonds via water molecules also with other residues</scene>. Water molecules are shown as red spheres. Rare-earth element <scene name='83/833267/Cv/6'>Yttrium ion binding site</scene>.
 </StructureSection>