Sandbox TYRP1: Difference between revisions
Faure Marina (talk | contribs) No edit summary |
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TYRP1 has six sites of N-glygosylation which are important for maturation of the protein (Asn 96, 104,181,304,350,385). On our 3D structure all these sites are glycosylated. | TYRP1 has six sites of N-glygosylation which are important for maturation of the protein (Asn 96, 104,181,304,350,385). On our 3D structure all these sites are glycosylated. | ||
The crystal structure of TYRP1 shows that TYRP1 can bind tyrosine, mimosine, kojic acid, tropolone. These substrates can bind to the enzyme thanks to aromatic stacking interactions with H381. The keto and hydroxy groups interact with Zinc ions and some hydrogen bonds are created with S394. | |||
=== The active site === | === The active site === | ||