Hsp70: Difference between revisions
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Hsp70 function is critical to homeostasis. Protein aggregation is not typically beneficial to most organisms. For example, protein aggregation in different areas of the brain can lead to certain neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Hsp70’s promotion of refolding is key to make the misfolded protein functional once again. The many members of the Hsp70 family are highly conserved <ref name="Evans">Evans, C. G., Chang, L., & Gestwicki, J. E. (2010). Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target. Journal of Medicinal Chemistry, 53(12), 4585-4602. doi:10.1021/jm100054f</ref>. This reinforces the presumption that these proteins are vital to most organisms. When something is widely expressed and highly conserved it tells us it has been beneficial to cells and organisms for a very long time and there was no need for change. | Hsp70 function is critical to homeostasis. Protein aggregation is not typically beneficial to most organisms. For example, protein aggregation in different areas of the brain can lead to certain neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Hsp70’s promotion of refolding is key to make the misfolded protein functional once again. The many members of the Hsp70 family are highly conserved <ref name="Evans">Evans, C. G., Chang, L., & Gestwicki, J. E. (2010). Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target. Journal of Medicinal Chemistry, 53(12), 4585-4602. doi:10.1021/jm100054f</ref>. This reinforces the presumption that these proteins are vital to most organisms. When something is widely expressed and highly conserved it tells us it has been beneficial to cells and organisms for a very long time and there was no need for change. | ||
See also [[Heat Shock Proteins]]. | |||
==''' Structure '''== | ==''' Structure '''== | ||