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==Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine diphosphate== | |||
<StructureSection load='6cvf' size='340' side='right'caption='[[6cvf]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6cvf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CVF FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CDP:CYTIDINE-5-DIPHOSPHATE'>CDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fgn|3fgn]], [[3fpa|3fpa]], [[3fmi|3fmi]], [[3fmf|3fmf]], [[4wop|4wop]], [[6cve|6cve]], [[6cvu|6cvu]], [[6cvv|6cvv]], [[6czb|6czb]], [[6czc|6czc]], [[6czd|6czd]], [[6cze|6cze]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bioD, Rv1570, MTCY336.33c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dethiobiotin_synthase Dethiobiotin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.3 6.3.3.3] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cvf OCA], [http://pdbe.org/6cvf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cvf RCSB], [http://www.ebi.ac.uk/pdbsum/6cvf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cvf ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BIOD_MYCTU BIOD_MYCTU]] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.<ref>PMID:20565114</ref> | |||
==See Also== | |||
*[[Dethiobiotin synthetase 3D structures|Dethiobiotin synthetase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Bruning, J | </StructureSection> | ||
[[Category: Thompson, A | [[Category: Dethiobiotin synthase]] | ||
[[Category: Wegener, K | [[Category: Large Structures]] | ||
[[Category: Myctu]] | |||
[[Category: Bruning, J B]] | |||
[[Category: Polyak, S W]] | |||
[[Category: Thompson, A P]] | |||
[[Category: Wegener, K L]] | |||
[[Category: Enzyme]] | |||
[[Category: Nucleotide triphosphate binding]] | |||
[[Category: Synthetase]] | |||
[[Category: Transferase]] | |||
Revision as of 11:46, 8 January 2020
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine diphosphateCrystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine diphosphate
Structural highlights
Function[BIOD_MYCTU] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.[1] See AlsoReferences
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