5ibw: Difference between revisions
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==Complex of MlcC bound to the tandem IQ motif of MyoC== | ==Complex of MlcC bound to the tandem IQ motif of MyoC== | ||
<StructureSection load='5ibw' size='340' side='right' caption='[[5ibw]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='5ibw' size='340' side='right'caption='[[5ibw]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5ibw]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IBW FirstGlance]. <br> | <table><tr><td colspan='2'>[[5ibw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Dicdi Dicdi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IBW FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DDB_G0289563 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 DICDI]), myoC, dmiC, DDB_G0276617 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 DICDI])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ibw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ibw OCA], [http://pdbe.org/5ibw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ibw RCSB], [http://www.ebi.ac.uk/pdbsum/5ibw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ibw ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ibw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ibw OCA], [http://pdbe.org/5ibw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ibw RCSB], [http://www.ebi.ac.uk/pdbsum/5ibw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ibw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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==See Also== | ==See Also== | ||
*[[Myosin|Myosin]] | *[[Myosin 3D Structures|Myosin 3D Structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Dicdi]] | |||
[[Category: Large Structures]] | |||
[[Category: Langelaan, D N]] | [[Category: Langelaan, D N]] | ||
[[Category: Smith, S P]] | [[Category: Smith, S P]] | ||
[[Category: Motor protein]] | [[Category: Motor protein]] | ||
[[Category: Myosin iq motif complex]] | [[Category: Myosin iq motif complex]] | ||
Revision as of 11:04, 8 January 2020
Complex of MlcC bound to the tandem IQ motif of MyoCComplex of MlcC bound to the tandem IQ motif of MyoC
Structural highlights
Function[MYOC_DICDI] Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Involved in the process of phagocytosis and appears to support streaming behavior.[1] Publication Abstract from PubMedMyosin light chains are key regulators of class 1 myosins and typically comprise two domains, with calmodulin being the archetypal example. They bind IQ motifs within the myosin neck region and amplify conformational changes in motor domain. A single lobe light chain, myosin light chain C (MlcC), was recently identified and shown to specifically bind to two sequentially divergent IQ motifs of the Dictyostelium myosin-1C. Towards providing a molecular basis of this interaction, the structures of apo-MlcC and a 2:1 MlcC:myosin-1C neck complex were determined. The two non-functional EF-hand motifs of MlcC pack together to form a globular four-helix bundle that opens up to expose a central hydrophobic groove, which interacts the N-terminal portion of the divergent IQ1 and IQ2 motifs. N- and C-terminal regions of MlcC make critical contacts that contribute to its specific interactions with the myosin-1C divergent IQ motifs; contacts that deviate from the traditional mode of calmodulin-IQ recognition. Structure of the single-lobe myosin light chain C in complex with the light chain-binding domains of myosin-1C provides insights into divergent IQ-motif recognition.,Langelaan DN, Liburd J, Yang Y, Miller E, Chitayat S, Crawley SW, Cote GP, Smith SP J Biol Chem. 2016 Jul 27. pii: jbc.M116.746313. PMID:27466369[2] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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