4xx0: Difference between revisions
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==CoA bound to pig GTP-specific succinyl-CoA synthetase== | ==CoA bound to pig GTP-specific succinyl-CoA synthetase== | ||
<StructureSection load='4xx0' size='340' side='right' caption='[[4xx0]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='4xx0' size='340' side='right'caption='[[4xx0]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4xx0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XX0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4xx0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XX0 FirstGlance]. <br> | ||
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</div> | </div> | ||
<div class="pdbe-citations 4xx0" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4xx0" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Succinyl-CoA synthetase|Succinyl-CoA synthetase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Pig]] | [[Category: Pig]] | ||
[[Category: Fraser, M E]] | [[Category: Fraser, M E]] | ||
Revision as of 10:51, 8 January 2020
CoA bound to pig GTP-specific succinyl-CoA synthetaseCoA bound to pig GTP-specific succinyl-CoA synthetase
Structural highlights
Function[SUCA_PIG] Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity (By similarity). [SUCB2_PIG] Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity). Publication Abstract from PubMedPig GTP-specific succinyl-CoA synthetase is an alphabeta-heterodimer. The crystal structure of the complex with the substrate CoA was determined at 2.1 A resolution. The structure shows CoA bound to the amino-terminal domain of the alpha-subunit, with the free thiol extending from the adenine portion into the site where the catalytic histidine residue resides. Structure of GTP-specific succinyl-CoA synthetase in complex with CoA.,Huang J, Malhi M, Deneke J, Fraser ME Acta Crystallogr F Struct Biol Commun. 2015 Aug 1;71(Pt 8):1067-71. doi:, 10.1107/S2053230X15011188. Epub 2015 Jul 29. PMID:26249701[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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