1ug3: Difference between revisions
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==C-terminal portion of human eIF4GI== | ==C-terminal portion of human eIF4GI== | ||
<StructureSection load='1ug3' size='340' side='right' caption='[[1ug3]], [[Resolution|resolution]] 2.24Å' scene=''> | <StructureSection load='1ug3' size='340' side='right'caption='[[1ug3]], [[Resolution|resolution]] 2.24Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ug3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UG3 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ug3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UG3 FirstGlance]. <br> | ||
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*[[C-terminal portion of human eIF4GI|C-terminal portion of human eIF4GI]] | *[[C-terminal portion of human eIF4GI|C-terminal portion of human eIF4GI]] | ||
*[[Death Associated Protein 5|Death Associated Protein 5]] | *[[Death Associated Protein 5|Death Associated Protein 5]] | ||
*[[Eukaryotic initiation factor|Eukaryotic initiation factor]] | *[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Bellsolell, L]] | [[Category: Bellsolell, L]] | ||
[[Category: Burley, S K]] | [[Category: Burley, S K]] | ||
Revision as of 16:16, 1 January 2020
C-terminal portion of human eIF4GIC-terminal portion of human eIF4GI
Structural highlights
Disease[IF4G1_HUMAN] Defects in EIF4G1 are the cause of Parkinson disease type 18 (PARK18) [MIM:614251]. An autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.[1] Function[IF4G1_HUMAN] Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also
References
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