6ivy: Difference between revisions
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<StructureSection load='6ivy' size='340' side='right'caption='[[6ivy]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='6ivy' size='340' side='right'caption='[[6ivy]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6ivy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IVY FirstGlance]. <br> | <table><tr><td colspan='2'>[[6ivy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IVY FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hitA, PA4687 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ivy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivy OCA], [http://pdbe.org/6ivy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ivy RCSB], [http://www.ebi.ac.uk/pdbsum/6ivy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivy ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ivy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivy OCA], [http://pdbe.org/6ivy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ivy RCSB], [http://www.ebi.ac.uk/pdbsum/6ivy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Gallium nitrate (Ganite) is a potential drug for the treatment of Pseudomonas aeruginosa infection. CRISPR/Cas9-based gene mutagenesis studies reveal that siderophore pyochelin-facilitated uptake and an ABC transporter are two major Ga(3+) internalization pathways in Pseudomonas aeruginosa (P. aeruginosa). Crystal structures reveal that Ga(3+) and Fe(3+) occupy exactly the same metal site of HitA, a periplasmic iron-binding protein of the ABC transporter system. The study provides a molecular basis for Ga(3+) internalization by P. aeruginosa and facilitates gallium-based antimicrobial drug development. | |||
Identification and Characterization of a Metalloprotein Involved in Gallium Internalization in Pseudomonas aeruginosa.,Guo Y, Li W, Li H, Xia W ACS Infect Dis. 2019 Oct 11;5(10):1693-1697. doi: 10.1021/acsinfecdis.9b00271., Epub 2019 Sep 5. PMID:31475514<ref>PMID:31475514</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6ivy" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Pseae]] | |||
[[Category: Li, H Y]] | [[Category: Li, H Y]] | ||
[[Category: Zhang, Z R]] | [[Category: Zhang, Z R]] | ||
Revision as of 14:17, 1 January 2020
Crystal structure of iron-bound HitA from Pseudomonas aeruginosaCrystal structure of iron-bound HitA from Pseudomonas aeruginosa
Structural highlights
Publication Abstract from PubMedGallium nitrate (Ganite) is a potential drug for the treatment of Pseudomonas aeruginosa infection. CRISPR/Cas9-based gene mutagenesis studies reveal that siderophore pyochelin-facilitated uptake and an ABC transporter are two major Ga(3+) internalization pathways in Pseudomonas aeruginosa (P. aeruginosa). Crystal structures reveal that Ga(3+) and Fe(3+) occupy exactly the same metal site of HitA, a periplasmic iron-binding protein of the ABC transporter system. The study provides a molecular basis for Ga(3+) internalization by P. aeruginosa and facilitates gallium-based antimicrobial drug development. Identification and Characterization of a Metalloprotein Involved in Gallium Internalization in Pseudomonas aeruginosa.,Guo Y, Li W, Li H, Xia W ACS Infect Dis. 2019 Oct 11;5(10):1693-1697. doi: 10.1021/acsinfecdis.9b00271., Epub 2019 Sep 5. PMID:31475514[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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