6tp3: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6tp3 is ON HOLD
+==Crystal structure of the Orexin-1 receptor in complex with daridorexant==
+<StructureSection load='6tp3' size='340' side='right'caption='[[6tp3]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6tp3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TP3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TP3 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NS2:[(2~{S})-2-(6-chloranyl-7-methyl-1~{H}-benzimidazol-2-yl)-2-methyl-pyrrolidin-1-yl]-[5-methoxy-2-(1,2,3-triazol-2-yl)phenyl]methanone'>NS2</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SOG:2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL'>SOG</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6tot|6tot]], [[6tos|6tos]], [[6tod|6tod]], [[6to7|6to7]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tp3 OCA], [http://pdbe.org/6tp3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tp3 RCSB], [http://www.ebi.ac.uk/pdbsum/6tp3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tp3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN]] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The orexin system, which consists of the two G protein-coupled receptors OX1 and OX2, activated by the neuropeptides OX-A and OX-B, is firmly established as a key regulator of behavioural arousal, sleep and wakefulness, and has been an area of intense research effort over the past two decades. X-ray structures of the receptors in complex with ten new antagonist ligands from diverse chemotypes are presented, which complement the existing structural information for the system and highlight the critical importance of lipophilic hotspots and water molecules for these peptidergic GPCR targets. Learnings from the structural information regarding the utility of pharmacophore models and how selectivity between OX1 and OX2 can be achieved are discussed.
-Authors: Rappas, M., Ali, A., Bennett, K.A., Brown, J.D., Bucknell, S.J., Congreve, M., Cooke, R.M., Cseke, G., de Graaf, C., Dore, A.S., Errey, J.C., Jazayeri, A., Marshall, F.H., Mason, J.S., Mould, R., Patel, J.C., Tehan, B.G., Weir, M., Christopher, J.A.
+Comparison of orexin 1 and orexin 2 ligand binding modes using X-ray crystallography and computational analysis.,Rappas M, Ali A, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Dore AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan B, Weir M, Christopher JA J Med Chem. 2019 Dec 20. doi: 10.1021/acs.jmedchem.9b01787. PMID:31860301<ref>PMID:31860301</ref>
-Description: Crystal structure of the Orexin-1 receptor in complex with daridorexant
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Weir, M]]
+<div class="pdbe-citations 6tp3" style="background-color:#fffaf0;"></div>
-[[Category: Tehan, B.G]]
+== References ==
-[[Category: Christopher, J.A]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Ali, A]]
+[[Category: Bennett, K A]]
+[[Category: Brown, J D]]
+[[Category: Bucknell, S J]]
+[[Category: Christopher, J A]]
 [[Category: Congreve, M]]
-[[Category: Mason, J.S]]
+[[Category: Cooke, R M]]
+[[Category: Cseke, G]]
+[[Category: Dore, A S]]
+[[Category: Errey, J C]]
+[[Category: Graaf, C de]]
 [[Category: Jazayeri, A]]
-[[Category: Bucknell, S.J]]
+[[Category: Marshall, F H]]
-[[Category: Cseke, G]]
+[[Category: Mason, J S]]
-[[Category: Marshall, F.H]]
-[[Category: Cooke, R.M]]
 [[Category: Mould, R]]
-[[Category: Brown, J.D]]
+[[Category: Patel, J C]]
-[[Category: Patel, J.C]]
-[[Category: Errey, J.C]]
-[[Category: De Graaf, C]]
 [[Category: Rappas, M]]
-[[Category: Ali, A]]
+[[Category: Tehan, B G]]
-[[Category: Dore, A.S]]
+[[Category: Weir, M]]
-[[Category: Bennett, K.A]]
+[[Category: Gpcr]]
+[[Category: Membrane protein]]