6ufm: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ufm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ufm OCA], [http://pdbe.org/6ufm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ufm RCSB], [http://www.ebi.ac.uk/pdbsum/6ufm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ufm ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ufm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ufm OCA], [http://pdbe.org/6ufm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ufm RCSB], [http://www.ebi.ac.uk/pdbsum/6ufm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ufm ProSAT]</span></td></tr> | ||
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== Publication Abstract from PubMed == | |||
T-box riboswitches are modular bacterial noncoding RNAs that sense and regulate amino acid availability through direct interactions with tRNAs. Between the 5' anticodon-binding stem I domain and the 3' amino acid sensing domains of most T-boxes lies the stem II domain of unknown structure and function. Here, we report a 2.8-A cocrystal structure of the Nocardia farcinica ileS T-box in complex with its cognate tRNA(Ile). The structure reveals a perpendicularly arranged ultrashort stem I containing a K-turn and an elongated stem II bearing an S-turn. Both stems rest against a compact pseudoknot, dock via an extended ribose zipper and jointly create a binding groove specific to the anticodon of its cognate tRNA. Contrary to proposed distal contacts to the tRNA elbow region, stem II locally reinforces the codon-anticodon interactions between stem I and tRNA, achieving low-nanomolar affinity. This study illustrates how mRNA junctions can create specific binding sites for interacting RNAs of prescribed sequence and structure. | |||
High-affinity recognition of specific tRNAs by an mRNA anticodon-binding groove.,Suddala KC, Zhang J Nat Struct Mol Biol. 2019 Dec;26(12):1114-1122. doi: 10.1038/s41594-019-0335-6., Epub 2019 Dec 2. PMID:31792448<ref>PMID:31792448</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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== References == | |||
<references/> | |||
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</StructureSection> | </StructureSection> | ||