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==Caspase-7 S239E Phosphomimetic== | ==Caspase-7 S239E Phosphomimetic== | ||
<StructureSection load='5k20' size='340' side='right' caption='[[5k20]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='5k20' size='340' side='right'caption='[[5k20]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5k20]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K20 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K20 FirstGlance]. <br> | <table><tr><td colspan='2'>[[5k20]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K20 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K20 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ibf|3ibf]], [[3s8e|3s8e]], [[1k86|1k86]], [[3r5k|3r5k]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ibf|3ibf]], [[3s8e|3s8e]], [[1k86|1k86]], [[3r5k|3r5k]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP7, MCH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k20 OCA], [http://pdbe.org/5k20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k20 RCSB], [http://www.ebi.ac.uk/pdbsum/5k20 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k20 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k20 OCA], [http://pdbe.org/5k20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k20 RCSB], [http://www.ebi.ac.uk/pdbsum/5k20 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k20 ProSAT]</span></td></tr> | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. | [[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. | ||
==See Also== | |||
*[[Caspase 3D structures|Caspase 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Caspase-7]] | [[Category: Caspase-7]] | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Eron, S J]] | [[Category: Eron, S J]] | ||
[[Category: Hardy, J A]] | [[Category: Hardy, J A]] | ||
Revision as of 15:07, 25 December 2019
Caspase-7 S239E PhosphomimeticCaspase-7 S239E Phosphomimetic
Structural highlights
Function[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. See Also |
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