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==Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 4-methylumbelliferone== | ==Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 4-methylumbelliferone== | ||
<StructureSection load='5jr3' size='340' side='right' caption='[[5jr3]], [[Resolution|resolution]] 1.84Å' scene=''> | <StructureSection load='5jr3' size='340' side='right'caption='[[5jr3]], [[Resolution|resolution]] 1.84Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5jr3]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1799 As 4.1799]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JR3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JR3 FirstGlance]. <br> | <table><tr><td colspan='2'>[[5jr3]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1799 As 4.1799]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JR3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JR3 FirstGlance]. <br> | ||
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[[Category: As 4 1799]] | [[Category: As 4 1799]] | ||
[[Category: Carminomycin 4-O-methyltransferase]] | [[Category: Carminomycin 4-O-methyltransferase]] | ||
[[Category: Large Structures]] | |||
[[Category: Huber, T D]] | [[Category: Huber, T D]] | ||
[[Category: Johnson, B R]] | [[Category: Johnson, B R]] | ||
Revision as of 15:05, 25 December 2019
Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 4-methylumbelliferoneCrystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 4-methylumbelliferone
Structural highlights
Function[DNRK_STRPE] Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. In vivo, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the 4-O-position of carminomycin to form daunorubicin. In vitro, it also methylates the anthracyclines rhodomycin D (10-carbomethoxy-13-deoxycarminomycin) and 13-deoxy-carminomycin at the 4-hydroxyl position. It is quite specific with respect to the length of the carbohydrate chain at the C7 position, but it can accept substrates with bulky substituent at C10 position.[1] References
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- As 4 1799
- Carminomycin 4-O-methyltransferase
- Large Structures
- Huber, T D
- Johnson, B R
- NatPro, Enzyme Discovery for Natural Product Biosynthesis
- Phillips, G N
- Singh, S
- Thorson, J S
- Wang, F
- Enzyme discovery for natural product biosynthesis
- Natpro
- Natural product biosynthesis
- PSI, Protein structure initiative
- Psi-biology
- Structural genomic
- Transferase