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==The hSac2 domain from human phosphoinositide phosphatase Sac2==
==The hSac2 domain from human phosphoinositide phosphatase Sac2==
<StructureSection load='4xuu' size='340' side='right' caption='[[4xuu]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
<StructureSection load='4xuu' size='340' side='right'caption='[[4xuu]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4xuu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XUU FirstGlance]. <br>
<table><tr><td colspan='2'>[[4xuu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XUU FirstGlance]. <br>
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== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SAC2_HUMAN SAC2_HUMAN]] Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.<ref>PMID:11274189</ref> <ref>PMID:17322895</ref>   
[[http://www.uniprot.org/uniprot/SAC2_HUMAN SAC2_HUMAN]] Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.<ref>PMID:11274189</ref> <ref>PMID:17322895</ref>   
==See Also==
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
*[[Phosphoinositide phosphatase|Phosphoinositide phosphatase]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Hsu, F]]
[[Category: Hsu, F]]
[[Category: Mao, Y]]
[[Category: Mao, Y]]

Revision as of 13:40, 25 December 2019

The hSac2 domain from human phosphoinositide phosphatase Sac2The hSac2 domain from human phosphoinositide phosphatase Sac2

Structural highlights

4xuu is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Gene:INPP5F, KIAA0966, SAC2, MSTP007, MSTP047 (HUMAN)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SAC2_HUMAN] Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.[1] [2]

See Also

References

  1. ↑ Minagawa T, Ijuin T, Mochizuki Y, Takenawa T. Identification and characterization of a sac domain-containing phosphoinositide 5-phosphatase. J Biol Chem. 2001 Jun 22;276(25):22011-5. Epub 2001 Mar 26. PMID:11274189 doi:http://dx.doi.org/10.1074/jbc.M101579200
  2. ↑ Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA. Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med. 2007 Mar;13(3):324-31. Epub 2007 Feb 18. PMID:17322895 doi:http://dx.doi.org/nm1552

4xuu, resolution 2.62Å

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