1a66: Difference between revisions

Revision as of 09:52, 2 May 2008

SOLUTION NMR STRUCTURE OF THE CORE NFATC1/DNA COMPLEX, 18 STRUCTURES

OverviewOverview

The nuclear factor of the activated T cell (NFAT) family of transcription factors regulates cytokine gene expression by binding to the promoter/enhancer regions of antigen-responsive genes, usually in cooperation with heterologous DNA-binding partners. Here we report the solution structure of the binary complex formed between the core DNA-binding domain of human NFATC1 and the ARRE2 DNA site from the interleukin-2 promoter. The structure reveals that DNA binding induces the folding of key structural elements that are required for both sequence-specific recognition and the establishment of cooperative protein-protein contacts. The orientation of the NFAT DNA-binding domain observed in the binary NFATC1-DBD*/ DNA complex is distinct from that seen in the ternary NFATC2/AP-1/DNA complex, suggesting that the domain reorients upon formation of a cooperative transcriptional complex.

About this StructureAbout this Structure

1A66 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Solution structure of the core NFATC1/DNA complex., Zhou P, Sun LJ, Dotsch V, Wagner G, Verdine GL, Cell. 1998 Mar 6;92(5):687-96. PMID:9506523 Page seeded by OCA on Fri May 2 09:52:13 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1a66.jpg|left|200px]]
- {{Structure
+<!--
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+The line below this paragraph, containing "STRUCTURE_1a66", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
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-|GENE= NFATC1(416-591) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+-->
-|DOMAIN=
+{{STRUCTURE_1a66|  PDB=1a66  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a66 OCA], [http://www.ebi.ac.uk/pdbsum/1a66 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a66 RCSB]</span>
-}}
 '''SOLUTION NMR STRUCTURE OF THE CORE NFATC1/DNA COMPLEX, 18 STRUCTURES'''
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 [[Category: Wagner, G.]]
 [[Category: Zhou, P.]]
-[[Category: arre2]]
+[[Category: Arre2]]
-[[Category: binary]]
+[[Category: Binary]]
-[[Category: binary complex]]
+[[Category: Binary complex]]
-[[Category: complex]]
+[[Category: Complex]]
-[[Category: enhanceosome]]
+[[Category: Enhanceosome]]
-[[Category: il-2]]
+[[Category: Il-2]]
-[[Category: nfat]]
+[[Category: Nfat]]
-[[Category: nfat/dna]]
+[[Category: Nfat/dna]]
-[[Category: nfat2]]
+[[Category: Nfat2]]
-[[Category: nfatc]]
+[[Category: Nfatc]]
-[[Category: nfatc1]]
+[[Category: Nfatc1]]
-[[Category: nfatc1/dna]]
+[[Category: Nfatc1/dna]]
-[[Category: nmr]]
+[[Category: Nmr]]
-[[Category: rel]]
+[[Category: Rel]]
-[[Category: transcription factor]]
+[[Category: Transcription factor]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:52:13 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:34:07 2008''