Hsp70: Difference between revisions
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Parkinson’s Disease is characterized by the continuing loss of dopaminergic neurons in the substantia nigra pars compacta, with subsequent dopamine decline in the nigrostriatal pathway, and by intracytoplasmic fibrillar <scene name='81/813405/Parkinsons_protein/1'>α-Synuclein</scene> protein aggregates (Lewy Bodies, LB) in the remaining nigral neurons. Hsp70 overexpression demonstrated reduced α-Syn accumulation and toxicity in both mouse and Drosophila Parkinson’s Disease Models <ref>Turturici, G., Sconzo, G., & Geraci, F. (2011). Hsp70 and Its Molecular Role in Nervous System Diseases. Biochemistry Research International, 2011, 1-18. doi:10.1155/2011/618127</ref>. | Parkinson’s Disease is characterized by the continuing loss of dopaminergic neurons in the substantia nigra pars compacta, with subsequent dopamine decline in the nigrostriatal pathway, and by intracytoplasmic fibrillar <scene name='81/813405/Parkinsons_protein/1'>α-Synuclein</scene> protein aggregates (Lewy Bodies, LB) in the remaining nigral neurons. Hsp70 overexpression demonstrated reduced α-Syn accumulation and toxicity in both mouse and Drosophila Parkinson’s Disease Models <ref>Turturici, G., Sconzo, G., & Geraci, F. (2011). Hsp70 and Its Molecular Role in Nervous System Diseases. Biochemistry Research International, 2011, 1-18. doi:10.1155/2011/618127</ref>. | ||
See also [[Heat Shock Proteins]] | |||
== References == | == References == | ||
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