1tgm: Difference between revisions
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==Crystal structure of a complex formed between group II phospholipase A2 and aspirin at 1.86 A resolution== | ==Crystal structure of a complex formed between group II phospholipase A2 and aspirin at 1.86 A resolution== | ||
<StructureSection load='1tgm' size='340' side='right' caption='[[1tgm]], [[Resolution|resolution]] 1.86Å' scene=''> | <StructureSection load='1tgm' size='340' side='right'caption='[[1tgm]], [[Resolution|resolution]] 1.86Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1tgm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_russellii Daboia russellii russellii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TGM FirstGlance]. <br> | <table><tr><td colspan='2'>[[1tgm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_russellii Daboia russellii russellii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TGM FirstGlance]. <br> | ||
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==See Also== | ==See Also== | ||
*[[Phospholipase A2|Phospholipase A2]] | *[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Daboia russellii russellii]] | [[Category: Daboia russellii russellii]] | ||
[[Category: Large Structures]] | |||
[[Category: Bhushan, A]] | [[Category: Bhushan, A]] | ||
[[Category: Jabeen, T]] | [[Category: Jabeen, T]] | ||
Revision as of 17:24, 18 December 2019
Crystal structure of a complex formed between group II phospholipase A2 and aspirin at 1.86 A resolutionCrystal structure of a complex formed between group II phospholipase A2 and aspirin at 1.86 A resolution
Structural highlights
Function[PA2B8_DABRR] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.[1] [2] [3] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See AlsoReferences
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