6dvm: Difference between revisions
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==Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with DDK-122== | ==Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with DDK-122== | ||
<StructureSection load='6dvm' size='340' side='right' caption='[[6dvm]], [[Resolution|resolution]] 1.47Å' scene=''> | <StructureSection load='6dvm' size='340' side='right'caption='[[6dvm]], [[Resolution|resolution]] 1.47Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6dvm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DVM FirstGlance]. <br> | <table><tr><td colspan='2'>[[6dvm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DVM FirstGlance]. <br> | ||
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</div> | </div> | ||
<div class="pdbe-citations 6dvm" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6dvm" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Brachidanio rerio]] | [[Category: Brachidanio rerio]] | ||
[[Category: Large Structures]] | |||
[[Category: Christianson, D W]] | [[Category: Christianson, D W]] | ||
[[Category: Porter, N J]] | [[Category: Porter, N J]] | ||
Revision as of 13:14, 18 December 2019
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with DDK-122Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with DDK-122
Structural highlights
Publication Abstract from PubMedFour crystal structures are presented of histone deacetylase 6 (HDAC6) complexes with para-substituted phenylhydromaxamate inhibitors, including bulky peptoids. These structures provide insight regarding the design of capping groups that confer selectivity for binding to HDAC6, specifically with regard to interactions in a pocket formed by the L1 loop. Capping group interactions may also influence hydroxamate-Zn(2+) coordination with monodentate or bidentate geometry. Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity.,Porter NJ, Osko JD, Diedrich D, Kurz T, Hooker JM, Hansen FK, Christianson DW J Med Chem. 2018 Aug 17. doi: 10.1021/acs.jmedchem.8b01013. PMID:30118224[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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