CAMP Dependent Protein Kinase, Catalytic Subunit: Difference between revisions
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<StructureSection load='1j3h' size='350' side='right' scene='' caption='Mouse CAMP-dependent protein kinase cdatalytic subunit with phosphothreonine, phosphoserine and MPD [[1j3h]]'> | |||
==Introduction== | ==Introduction== | ||
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==Interaction with Substrate== | ==Interaction with Substrate== | ||
The larger C-terminal lobe of the kinase is responsible for substrate recognition. Several of the c-term lobes alpha helices are important in determining substrate recognition. The substrate mimic inhibitor <scene name='CAMP_Dependent_Protein_Kinase,_Catalytic_Subunit/Pki/1'>PKI</scene> demonstrates this nicely. The PKI inhibitor is a heat shock protein. It sits firmly within the catalytic cleft of the enzyme. <ref>PMID: 8443157</ref> | The larger C-terminal lobe of the kinase is responsible for substrate recognition. Several of the c-term lobes alpha helices are important in determining substrate recognition. The substrate mimic inhibitor <scene name='CAMP_Dependent_Protein_Kinase,_Catalytic_Subunit/Pki/1'>PKI</scene> demonstrates this nicely. The PKI inhibitor is a heat shock protein. It sits firmly within the catalytic cleft of the enzyme. <ref>PMID: 8443157</ref> | ||
</StructureSection> | |||
==3D structures of CAMP-dependent protein kinase== | ==3D structures of CAMP-dependent protein kinase== | ||