1a3k: Difference between revisions

Revision as of 09:45, 2 May 2008

X-RAY CRYSTAL STRUCTURE OF THE HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN (CRD) AT 2.1 ANGSTROM RESOLUTION

OverviewOverview

Galectins are a family of lectins which share similar carbohydrate recognition domains (CRDs) and affinity for small beta-galactosides, but which show significant differences in binding specificity for more complex glycoconjugates. We report here the x-ray crystal structure of the human galectin-3 CRD, in complex with lactose and N-acetyllactosamine, at 2.1-A resolution. This structure represents the first example of a CRD determined from a galectin which does not show the canonical 2-fold symmetric dimer organization. Comparison with the published structures of galectins-1 and -2 provides an explanation for the differences in carbohydrate-binding specificity shown by galectin-3, and for the fact that it fails to form dimers by analogous CRD-CRD interactions.

About this StructureAbout this Structure

1A3K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution., Seetharaman J, Kanigsberg A, Slaaby R, Leffler H, Barondes SH, Rini JM, J Biol Chem. 1998 May 22;273(21):13047-52. PMID:9582341 Page seeded by OCA on Fri May 2 09:45:36 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1a3k.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1a3k |SIZE=350|CAPTION= <scene name='initialview01'>1a3k</scene>, resolution 2.1&Aring;
+The line below this paragraph, containing "STRUCTURE_1a3k", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1a3k|  PDB=1a3k  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3k OCA], [http://www.ebi.ac.uk/pdbsum/1a3k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a3k RCSB]</span>
-}}
 '''X-RAY CRYSTAL STRUCTURE OF THE HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN (CRD) AT 2.1 ANGSTROM RESOLUTION'''
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 [[Category: Seetharaman, J.]]
 [[Category: Slaaby, R.]]
-[[Category: galaptin]]
+[[Category: Galaptin]]
-[[Category: galectin]]
+[[Category: Galectin]]
-[[Category: ige-binding protein]]
+[[Category: Ige-binding protein]]
-[[Category: lectin]]
+[[Category: Lectin]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:45:36 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:32:26 2008''