6h03: Difference between revisions

==OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX==

== Structural highlights ==

<table><tr><td colspan='2'>[[6h03]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H03 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H03 FirstGlance]. <br>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h03 OCA], [http://pdbe.org/6h03 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h03 RCSB], [http://www.ebi.ac.uk/pdbsum/6h03 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h03 ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/CO6_HUMAN CO6_HUMAN]] Defects in C6 are the cause of complement component 6 deficiency (C6D) [MIM:[http://omim.org/entry/612446 612446]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. [[http://www.uniprot.org/uniprot/CO7_HUMAN CO7_HUMAN]] Immunodeficiency due to a late component of complement deficiency. Disease susceptibility is associated with variations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/CO9_HUMAN CO9_HUMAN]] Age-related macular degeneration;Immunodeficiency due to a late component of complements deficiency. Disease susceptibility is associated with variations affecting the gene represented in this entry.  Disease susceptibility is associated with variations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/CO8B_HUMAN CO8B_HUMAN]] Immunodeficiency due to a late component of complements deficiency. Disease susceptibility is associated with variations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:[http://omim.org/entry/609536 609536]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.  Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705). [[http://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1) [MIM:[http://omim.org/entry/613790 613790]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.  

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Boyd, C M]]

[[Category: Bubeck, D]]