6ctb: Difference between revisions

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-'''Unreleased structure'''
-The entry 6ctb is ON HOLD  until Paper Publication
+==Apo-Calmodulin Bound to Calcium Voltage Gated Channel 1.2 IQ-Motif==
+<StructureSection load='6ctb' size='340' side='right'caption='[[6ctb]], [[NMR_Ensembles_of_Models | 4 NMR models]]' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ctb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog] and [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CTB FirstGlance]. <br>
-Description:
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">calm1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog]), CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ctb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ctb OCA], [http://pdbe.org/6ctb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ctb RCSB], [http://www.ebi.ac.uk/pdbsum/6ctb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ctb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CALM1_XENLA CALM1_XENLA]] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. [[http://www.uniprot.org/uniprot/CAC1C_RABIT CAC1C_RABIT]] Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function (By similarity).
+__TOC__
+</StructureSection>
+[[Category: African clawed frog]]
+[[Category: European rabbit]]
+[[Category: Large Structures]]
+[[Category: Ames, J B]]
+[[Category: Anderson, D E]]
+[[Category: Turner, M L]]
+[[Category: Apo-calmodulin]]
+[[Category: Calcium]]
+[[Category: Calmodulin]]
+[[Category: Cav1 2]]
+[[Category: Neuronal signaling]]
+[[Category: Protein binding]]
+[[Category: Surface expression]]
+[[Category: Voltage gated channel]]