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==Atomic Resolution X-Ray Crystal Structure of a Ruthenocene Conjugated Beta-Lactam Antibiotic in Complex with CTX-M-14 E166A Beta-Lactamase== | ==Atomic Resolution X-Ray Crystal Structure of a Ruthenocene Conjugated Beta-Lactam Antibiotic in Complex with CTX-M-14 E166A Beta-Lactamase== | ||
<StructureSection load='4xxr' size='340' side='right' caption='[[4xxr]], [[Resolution|resolution]] 1.18Å' scene=''> | <StructureSection load='4xxr' size='340' side='right'caption='[[4xxr]], [[Resolution|resolution]] 1.18Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4xxr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XXR FirstGlance]. <br> | <table><tr><td colspan='2'>[[4xxr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XXR FirstGlance]. <br> | ||
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</div> | </div> | ||
<div class="pdbe-citations 4xxr" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4xxr" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Bacillus coli migula 1895]] | [[Category: Bacillus coli migula 1895]] | ||
[[Category: Beta-lactamase]] | [[Category: Beta-lactamase]] | ||
[[Category: Large Structures]] | |||
[[Category: Chen, Y]] | [[Category: Chen, Y]] | ||
[[Category: Lewandowski, E M]] | [[Category: Lewandowski, E M]] | ||
[[Category: Beta-lactamase organometallic ruthenocene ctx-m-14]] | [[Category: Beta-lactamase organometallic ruthenocene ctx-m-14]] | ||
[[Category: Hydrolase-antibiotic complex]] | [[Category: Hydrolase-antibiotic complex]] | ||
Revision as of 18:50, 11 December 2019
Atomic Resolution X-Ray Crystal Structure of a Ruthenocene Conjugated Beta-Lactam Antibiotic in Complex with CTX-M-14 E166A Beta-LactamaseAtomic Resolution X-Ray Crystal Structure of a Ruthenocene Conjugated Beta-Lactam Antibiotic in Complex with CTX-M-14 E166A Beta-Lactamase
Structural highlights
Publication Abstract from PubMedWe have determined a 1.18 A resolution X-ray crystal structure of a novel ruthenocenyle-6-aminopenicillinic acid in complex with CTX-M beta-lactamase, showing unprecedented details of interactions between ruthenocene and protein. As the first product complex with an intact catalytic serine, the structure also offers insights into beta-lactamase catalysis and inhibitor design. Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated beta-lactam antibiotic.,Lewandowski EM, Skiba J, Torelli NJ, Rajnisz A, Solecka J, Kowalski K, Chen Y Chem Commun (Camb). 2015 Mar 10. PMID:25753149[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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