6iwi: Difference between revisions

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-'''Unreleased structure'''
-The entry 6iwi is ON HOLD  until Paper Publication
+==Crystal structure of PDE5A in complex with a novel inhibitor==
+<StructureSection load='6iwi' size='340' side='right'caption='[[6iwi]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
-Authors: Zhang, X.L., Xu, Y.C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6iwi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IWI FirstGlance]. <br>
-Description: Crystal structure of PDE5A in complex with a novel inhibitor
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B0C:N-[3-(4,5-diethyl-6-oxo-1,6-dihydropyrimidin-2-yl)-4-propoxyphenyl]-2-(4-methylpiperazin-1-yl)acetamide'>B0C</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35] </span></td></tr>
-[[Category: Zhang, X.L]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6iwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iwi OCA], [http://pdbe.org/6iwi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iwi RCSB], [http://www.ebi.ac.uk/pdbsum/6iwi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iwi ProSAT]</span></td></tr>
-[[Category: Xu, Y.C]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
+__TOC__
+</StructureSection>
+[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
+[[Category: Large Structures]]
+[[Category: Xu, Y C]]
+[[Category: Zhang, X L]]
+[[Category: Complex structure]]
+[[Category: Hydrolase]]
+[[Category: Inhibitor]]
+[[Category: Pde5a]]