Ragulator complex: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
Michal Harel (talk | contribs)
31,761 edits
No edit summary
Michal Harel (talk | contribs)
31,761 edits
No edit summary
Line 12: Line 12:
[[5y39]], [[5y3a]], [[6ehp]] - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5  <br />
[[5y39]], [[5y3a]], [[6ehp]] - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5  <br />
[[5x6u]] - hLAMTOR1 (mutant) + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5  <br />
[[5x6u]] - hLAMTOR1 (mutant) + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5  <br />
[[5yk3]] - hLAMTOR1 + LAMTOR2 (mutant) + LAMTOR3 + LAMTOR4 (mutant) + LAMTOR5  <br />
[[6ehr]] - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5  + Ras-related GTP-binding proteins A, C <br />
[[6ehr]] - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5  + Ras-related GTP-binding proteins A, C <br />
[[5x6v]] - hLAMTOR1 (mutant) + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5  + Ras-related GTP-binding proteins A, C <br />
[[5x6v]] - hLAMTOR1 (mutant) + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5  + Ras-related GTP-binding proteins A, C <br />
[[5vok]], [[5y38]] - hLAMTOR4 + LAMTOR5<br />
[[6ulg]] - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5  + Folliculin + folliculin-interactin protein + Ras-related GTP-binding proteins A, C – Cryo EM<br />
[[6nzd]] - hLAMTOR1 (mutant) + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5  + Folliculin + folliculin-interactin protein + Ras-related GTP-binding proteins A, C – Cryo EM<br />
[[6u62]] - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5  + RAPTOR + Ras-related GTP-binding proteins A, C – Cryo EM<br />[[5vok]], [[5y38]], [[5yk5]] - hLAMTOR4 + LAMTOR5<br />


== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 12:14, 8 December 2019


The ragulator complex (Lamtor) is a pentamer which recruits mTORC1 in the rapamycin (mTOR) signal-transduction pathway and activates it[1].


Human ragulator complex proteins: LAMTOR1 coiled coil domain (grey and cyan) + LAMTOR2 roadblock domain (green and red) + LAMTOR3 roadblock domain (pink and gold) + LAMTOR4 roadblock domain (yellow and wheat) + LAMTOR5 roadblock domain (magenta and blue) PDB code 5y39

Drag the structure with the mouse to rotate

3D structures of ragulator complex3D structures of ragulator complex

Updated on 08-December-2019

6b9x - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + hepatitis B virus interacting protein - human
5y39, 5y3a, 6ehp - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5
5x6u - hLAMTOR1 (mutant) + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5
5yk3 - hLAMTOR1 + LAMTOR2 (mutant) + LAMTOR3 + LAMTOR4 (mutant) + LAMTOR5
6ehr - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5 + Ras-related GTP-binding proteins A, C
5x6v - hLAMTOR1 (mutant) + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5 + Ras-related GTP-binding proteins A, C
6ulg - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5 + Folliculin + folliculin-interactin protein + Ras-related GTP-binding proteins A, C – Cryo EM
6nzd - hLAMTOR1 (mutant) + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5 + Folliculin + folliculin-interactin protein + Ras-related GTP-binding proteins A, C – Cryo EM
6u62 - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5 + RAPTOR + Ras-related GTP-binding proteins A, C – Cryo EM
5vok, 5y38, 5yk5 - hLAMTOR4 + LAMTOR5

ReferencesReferences

  1. ↑ Mu Z, Wang L, Deng W, Wang J, Wu G. Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane. Cell Discov. 2017 Dec 26;3:17049. doi: 10.1038/celldisc.2017.49. eCollection, 2017. PMID:29285400 doi:http://dx.doi.org/10.1038/celldisc.2017.49

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Wayne Decatur
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=Ragulator_complex&oldid=3122675"