4tss: Difference between revisions
No edit summary |
No edit summary |
||
| Line 27: | Line 27: | ||
[[Category: toxin]] | [[Category: toxin]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 18:49:38 2007'' | ||
Revision as of 19:44, 5 November 2007
|
TOXIC SHOCK SYNDROME TOXIN-1: TETRAGONAL P4(1)2(1)2 CRYSTAL FORM
OverviewOverview
The structure of toxic shock syndrome toxin-1 (TSST-1), the causative, agent in toxic shock syndrome, has been determined in three crystal forms., The three structural models have been refined to R-factors of 0.154, 0.150, and 0.198 at resolutions of 2.05 A, 2.90 A, and 2.75 A, respectively. One crystal form of TSST-1 contains a zinc ion bound between, two symmetry-related molecules. Although not required for biological, activity, zinc dramatically potentiates the mitogenicity of TSST-1 at very, low concentrations. In addition, the structure of the tetramutant TSST-1H, [T69I, Y80W, E132K, I140T], which is nonmitogenic and does not amplify, endotoxin shock, has been determined and refined in a fourth crystal form, (R-factor = 0.173 to 1.9 A resolution).
About this StructureAbout this Structure
4TSS is a Single protein structure of sequence from Staphylococcus aureus with ZN as ligand. Structure known Active Site: ZN. Full crystallographic information is available from OCA.
ReferenceReference
Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity., Prasad GS, Radhakrishnan R, Mitchell DT, Earhart CA, Dinges MM, Cook WJ, Schlievert PM, Ohlendorf DH, Protein Sci. 1997 Jun;6(6):1220-7. PMID:9194182
Page seeded by OCA on Mon Nov 5 18:49:38 2007