6kyh: Difference between revisions

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'''Unreleased structure'''


The entry 6kyh is ON HOLD until Paper Publication
==Crystal structure of Shank3 NTD-ANK A42K mutant in complex with HRas==
 
<StructureSection load='6kyh' size='340' side='right'caption='[[6kyh]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6kyh]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KYH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KYH FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kyh OCA], [http://pdbe.org/6kyh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kyh RCSB], [http://www.ebi.ac.uk/pdbsum/6kyh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kyh ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/SHAN3_MOUSE SHAN3_MOUSE]] Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.<ref>PMID:21423165</ref> <ref>PMID:21558424</ref> <ref>PMID:23739967</ref> <ref>PMID:24153177</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Cai, Q]]
[[Category: Zhang, M]]
[[Category: Gtpase]]
[[Category: Shank3]]
[[Category: Structural protein-signaling protein complex]]
[[Category: Synaptic scaffold protein]]

Revision as of 11:06, 4 December 2019

Crystal structure of Shank3 NTD-ANK A42K mutant in complex with HRasCrystal structure of Shank3 NTD-ANK A42K mutant in complex with HRas

Structural highlights

6kyh is a 8 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SHAN3_MOUSE] Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.[1] [2] [3] [4]

References

  1. ↑ Peca J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TN, Lascola CD, Fu Z, Feng G. Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature. 2011 Apr 28;472(7344):437-42. doi: 10.1038/nature09965. Epub 2011 Mar 20. PMID:21423165 doi:http://dx.doi.org/10.1038/nature09965
  2. ↑ Wang X, McCoy PA, Rodriguiz RM, Pan Y, Je HS, Roberts AC, Kim CJ, Berrios J, Colvin JS, Bousquet-Moore D, Lorenzo I, Wu G, Weinberg RJ, Ehlers MD, Philpot BD, Beaudet AL, Wetsel WC, Jiang YH. Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum Mol Genet. 2011 Aug 1;20(15):3093-108. doi: 10.1093/hmg/ddr212. Epub 2011 May, 10. PMID:21558424 doi:http://dx.doi.org/10.1093/hmg/ddr212
  3. ↑ Raynaud F, Janossy A, Dahl J, Bertaso F, Perroy J, Varrault A, Vidal M, Worley PF, Boeckers TM, Bockaert J, Marin P, Fagni L, Homburger V. Shank3-Rich2 interaction regulates AMPA receptor recycling and synaptic long-term potentiation. J Neurosci. 2013 Jun 5;33(23):9699-715. doi: 10.1523/JNEUROSCI.2725-12.2013. PMID:23739967 doi:http://dx.doi.org/10.1523/JNEUROSCI.2725-12.2013
  4. ↑ Han K, Holder JL Jr, Schaaf CP, Lu H, Chen H, Kang H, Tang J, Wu Z, Hao S, Cheung SW, Yu P, Sun H, Breman AM, Patel A, Lu HC, Zoghbi HY. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature. 2013 Nov 7;503(7474):72-7. doi: 10.1038/nature12630. Epub 2013 Oct 23. PMID:24153177 doi:http://dx.doi.org/10.1038/nature12630

6kyh, resolution 3.30Å

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