Proliferating Cell Nuclear Antigen: Difference between revisions

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</StructureSection>
</StructureSection>


== 3D Structures of Proliferating Cell Nuclear Antigen ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Unliganded PCNA
**[[1vym]], [[1w60]], [[3vkx]] – hPCNA - human<br />
**[[5mom]], [[5e0t]] – hPCNA (mutant)<br />
**[[3lox]], [[1plq]], [[1plr]], [[4yhr]], [[5t9d]] – yPCNA - yeast<br />
**[[3f1x]], [[3gpm]], [[3gpn]], [[3f1w]], [[4l60]], [[4l6p]], [[6cx2]], [[6cx3]], [[6cx4]], [[5v7m]], [[5v7l]], [[5v7k]], [[6d0r]], [[6d0q]], [[6cx4]], [[6cx3]], [[6cx2]] - yPCNA (mutant)<br />
**[[3l0x]] - yPCNA N fragment + C fragment<br />
**[[3pge]] - yPCNA N fragment + SUMO-C fragment<br />
**[[5e0t]], [[5mom]] - hPCNA (mutant)<br />
**[[2io4]] – SsPCNA B (mutant) + PCNA C - ''Sulfolobus solfataricus''<br />
**[[2hii]], [[2hik]], [[2ixi]], [[2ix2]] - SsPCNA A + PCNA B + PCNA C<br />
**[[2nti]] - SsPCNA A + PCNA B (mutant) + PCNA C<br />
**[[2ijx]] - SsPCNA A<br />
**[[1iz4]], [[1iz5]], [[1ge8]], [[5auj]] – PfPCNA (mutant) - ''Pyrococcus furiosus''<br />
**[[3hi8]], [[3ifv]] - PCNA - ''Haloferax volcanii''<br />
**[[3aix]], [[3aiz]] - StPCNA B + PCNA C – ''Sulfolobus tokodaii''<br />
**[[1ud9]] - StPCNA<br />
**[[3p91]] – PCNA – ''Entamoeba histoytiica''<br />
**[[4hk1]] – PCNA – ''Drosophila melanogaster''<br />
**[[4cs5]] – PCNA – ''Litopenaeus vannamei''<br />
**[[5cfk]], [[5b7o]], [[5h0t]], [[5hac]] - PCNA - ''Leishmania donovani''<br />
**[[1rwz]] – AfPCNA - ''Archaeglobus fulgidus''<br />
**[[3lx1]] - TkPCNA1 - ''Thermococcus kodakarensis''<br />
**[[5a6d]] - PCNA - ''Thermococcus gammatolerans''<br />
**[[3lx2]] - TkPCNA2<br />
*PCNA + Dpo
**[[6hvo]] - hPCNA + hDpo δ<br />
**[[2zvk]] – hPCNA + hDpo ε<br />
**[[2zvl]] – hPCNA + hDpo κ<br />
**[[2zvm]] – hPCNA + hDpo τ<br />
**[[3fds]] – SsPCNA B + PCNA C + SsDpo IV<br />
**[[3a2f]] - PfPCNA + Dpo<br />
*PCNA complexes
**[[1vyj]], [[1u76]], [[1u7b]], [[6cbi]], [[5yd8]], [[5yco]], [[5mlw]], [[5mlo]], [[5mav]], [[5iy4]], [[4ztd]], [[4rjf]], [[6fcn]] – hPCNA + peptide<br />
**[[5e0u]] - hPCNA (mutant) + peptide<br />
**[[4d2g]], [[6gws]] – hPCNA + p15 peptide<br />
**[[6e49]] – hPCNA + DNA helicase peptide<br />
**[[6eht]] – hPCNA + p15 peptide + DNA<br />
**[[5e0v]] - hPCNA + Flap structure-specific endonuclease peptide<br />
**[[6qcg]] – hPCNA + CDT1 peptide<br />
**[[6qc0]] – hPCNA + CDT2 peptide<br />
**[[6k3a]] – hPCNA + DNMT1 peptide<br />
**[[6e49]] – hPCNA + PIF-1 peptide<br />
**[[6cbi]] – hPCNA + peptide inhibitor<br />
**[[6gws]] – hPCNA + PCNA-associated factor peptide<br />
**[[6eht]] – hPCNA + PCNA-associated factor peptide + DNA<br />
**[[4ztd]] - hPCNA + ubiquitin ligase peptide<br />
**[[3wgw]] – hPCNA + inhibitor<br />
**[[6gis]] – hPCNA + DNA<br />
**[[4rjf]] - hPCNA + p21 peptide<br />
**[[5e0u]] - hPCNA (mutant) + p21<br />
**[[1axc]] - hPCNA + P21/WAF1 C-terminat<br />
**[[1ul1]] - hPCNA + Flap exonuclease-1<br />
**[[5e0v]] - hPCNA (mutant) + Flap endonoclease 1 <br />
**[[3p87]] - hPCNA + RNase H2 subunit B (mutant)<br />
**[[3tbl]] - hPCNA + ubiquitin<br />
**[[5iy4]] - hPCNA + DVC1 PIP box<br />
**[[5mlo]], [[5mlw]] - hPCNA + ZRANB3 peptide<br />
**[[5mav]] - hPCNA + PARG peptidee<br />
**[[6gis]] - hPCNA + DNA<br />
**[[3l0w]], [[3l10]] - yPCNA + monoubiquinated PCNA<br />
**[[1sxj]] – yPCNA + replication factor C<br />
**[[2od8]] - yPCNA + DNA ligase fragment<br />
**[[3k4x]] - yPCNA + DNA<br />
**[[3v60]], [[3v61]] – yPCNA (mutant) + ubiquitin-like protein SMT3<br />
**[[3v62]] – yPCNA (mutant) + ubiquitin-like protein SMT3 + ATP-dependent DNA helicase SRS2<br />
**[[5zut]] – yPCNA + peptide <br />
**[[5jne]] - yPCNA (mutant) + SMT3 + E2<br />
**[[2izo]] - SsPCNA B + PCNA C + Flap structure-specific endonuclease<br />
**[[1isq]] - PfPCNA (mutant) + replication factor C large subunit<br />
**[[2zvw]], [[2zvv]] - AtPCNA + cyclin-dependent kinase inhibitor 1 - ''Arabidopsis thaliana''<br />
**[[6o09]] – AtPCNA + peptide<br />
**[[5da7]] - TkPCNA + protein inhibitor<br />
**[[3p83]] - AfPCNA + RNase H2<br />
**[[1rxm]] – AfPCNA + Flap exonuclease-1 peptide<br />
**[[1rxz]] - AfPCNA + Flap structure-specific endonuclease<br />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 14:38, 27 November 2019

Function

Proliferating Cell Nuclear Antigen (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells[1].

Relevance

PCNA is useful in the diagnosis of high-grade dysplasia[2].

Structural highlights

p15 regulates DNA replication and repair by binding to PCNA. PCNA-p15 peptide complex shows the and has [3].

3D Structures of Proliferating Cell Nuclear Antigen

Proliferating cell nuclear antigen 3D structures


Human proliferating cell nuclear antigen trimer (cyan, green, deeppink) complex with p15 peptide (yellow, magenta) (PDB entry 4d2g)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Maga G, Hubscher U. Proliferating cell nuclear antigen (PCNA): a dancer with many partners. J Cell Sci. 2003 Aug 1;116(Pt 15):3051-60. PMID:12829735 doi:http://dx.doi.org/10.1242/jcs.00653
  2. ↑ Kullmann F, Fadaie M, Gross V, Knuchel R, Bocker T, Steinbach P, Scholmerich J, Ruschoff J. Expression of proliferating cell nuclear antigen (PCNA) and Ki-67 in dysplasia in inflammatory bowel disease. Eur J Gastroenterol Hepatol. 1996 Apr;8(4):371-9. PMID:8781908
  3. ↑ De Biasio A, de Opakua AI, Mortuza GB, Molina R, Cordeiro TN, Castillo F, Villate M, Merino N, Delgado S, Gil-Carton D, Luque I, Diercks T, Bernado P, Montoya G, Blanco FJ. Structure of p15(PAF)-PCNA complex and implications for clamp sliding during DNA replication and repair. Nat Commun. 2015 Mar 12;6:6439. doi: 10.1038/ncomms7439. PMID:25762514 doi:http://dx.doi.org/10.1038/ncomms7439

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Alexander Berchansky, Michal Harel, Joel L. Sussman, Lukáš Cakl
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