1a02: Difference between revisions

Revision as of 09:36, 2 May 2008

STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA

OverviewOverview

The nuclear factor of activated T cells (NFAT) and the AP-1 heterodimer, Fos-Jun, cooperatively bind a composite DNA site and synergistically activate the expression of many immune-response genes. A 2.7-A-resolution crystal structure of the DNA-binding domains of NFAT, Fos and Jun, in a quaternary complex with a DNA fragment containing the distal antigen-receptor response element from the interleukin-2 gene promoter, shows an extended interface between NFAT and AP-1, facilitated by the bending of Fos and DNA. The tight association of the three proteins on DNA creates a continuous groove for the recognition of 15 base pairs.

About this StructureAbout this Structure

1A02 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA., Chen L, Glover JN, Hogan PG, Rao A, Harrison SC, Nature. 1998 Mar 5;392(6671):42-8. PMID:9510247 Page seeded by OCA on Fri May 2 09:36:22 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1a02.gif|left|200px]]
- {{Structure
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-|GENE= NFAT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+-->
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-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a02 OCA], [http://www.ebi.ac.uk/pdbsum/1a02 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a02 RCSB]</span>
-}}
 '''STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA'''
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 [[Category: Hogan, P G.]]
 [[Category: Rao, A.]]
-[[Category: ap-1]]
+[[Category: Ap-1]]
-[[Category: combinatorial gene regulation]]
+[[Category: Combinatorial gene regulation]]
-[[Category: fos-jun]]
+[[Category: Fos-jun]]
-[[Category: nf-at]]
+[[Category: Nf-at]]
-[[Category: nfat]]
+[[Category: Nfat]]
-[[Category: quaternary protein-dna complex]]
+[[Category: Quaternary protein-dna complex]]
-[[Category: transcription factor]]
+[[Category: Transcription factor]]
-[[Category: transcription synergy]]
+[[Category: Transcription synergy]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:36:22 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:30:13 2008''