1psl: Difference between revisions
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==COMPUTATIONAL SEARCHING AND MUTAGENESIS SUGGEST A STRUCTURE FOR THE PENTAMERIC TRANSMEMBRANE DOMAIN OF PHOSPHOLAMBAN== | ==COMPUTATIONAL SEARCHING AND MUTAGENESIS SUGGEST A STRUCTURE FOR THE PENTAMERIC TRANSMEMBRANE DOMAIN OF PHOSPHOLAMBAN== | ||
<StructureSection load='1psl' size='340' side='right' caption='[[1psl]]' scene=''> | <StructureSection load='1psl' size='340' side='right'caption='[[1psl]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSL FirstGlance]. <br> | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSL FirstGlance]. <br> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Theoretical Model]] | [[Category: Theoretical Model]] | ||
[[Category: Large Structures]] | |||
[[Category: Adams, P D]] | [[Category: Adams, P D]] | ||
[[Category: Arkin, I T]] | [[Category: Arkin, I T]] | ||
[[Category: Brunger, A T]] | [[Category: Brunger, A T]] | ||
[[Category: Engelman, D M]] | [[Category: Engelman, D M]] | ||
Revision as of 13:03, 27 November 2019
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COMPUTATIONAL SEARCHING AND MUTAGENESIS SUGGEST A STRUCTURE FOR THE PENTAMERIC TRANSMEMBRANE DOMAIN OF PHOSPHOLAMBANCOMPUTATIONAL SEARCHING AND MUTAGENESIS SUGGEST A STRUCTURE FOR THE PENTAMERIC TRANSMEMBRANE DOMAIN OF PHOSPHOLAMBAN
Structural highlights
Publication Abstract from PubMedStructural and environmental constraints greatly simplify the folding problem for membrane proteins. Computational methods can be used in a global search to find a small number of chemically reasonable models within these constraints, such that a modest set of experimental data can distinguish among them. We show that, for phospholamban, the global search can be further simplified by reducing the problem to two-body, rather than many-body, interactions. This method of a constrained global search combined with experimental mutagenesis data yields a three-dimensional structure for this pentameric ion channel. The model is a left-handed symmetric homopentamer of alpha-helices with a well-defined channel, lined solely by hydrophobic residues. Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban.,Adams PD, Arkin IT, Engelman DM, Brunger AT Nat Struct Biol. 1995 Feb;2(2):154-62. PMID:7749920[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References |
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