6t8n: Difference between revisions
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==Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K3007== | |||
<StructureSection load='6t8n' size='340' side='right'caption='[[6t8n]], [[Resolution|resolution]] 1.77Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6t8n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T8N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6T8N FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MVE:cyclopropyl-[4-[6-[5-(4-ethoxy-1-propan-2-yl-piperidin-4-yl)pyridin-2-yl]pyrrolo[1,2-b]pyridazin-4-yl]piperazin-1-yl]methanone'>MVE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein_serine/threonine_kinase Receptor protein serine/threonine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.30 2.7.11.30] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6t8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t8n OCA], [http://pdbe.org/6t8n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t8n RCSB], [http://www.ebi.ac.uk/pdbsum/6t8n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t8n ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN]] Fibrodysplasia ossificans progressiva. Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:[http://omim.org/entry/135100 135100]]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.<ref>PMID:16642017</ref> <ref>PMID:19085907</ref> <ref>PMID:19330033</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN]] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity). | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Receptor protein serine/threonine kinase]] | |||
[[Category: Adamson, R J]] | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bacos, D]] | |||
[[Category: Bonomo, S]] | [[Category: Bonomo, S]] | ||
[[Category: | [[Category: Bountra, C]] | ||
[[Category: | [[Category: Bullock, A N]] | ||
[[Category: Burgess-Brown, N]] | [[Category: Burgess-Brown, N]] | ||
[[Category: Cramp, S]] | [[Category: Cramp, S]] | ||
[[Category: | [[Category: Delft, F von]] | ||
[[Category: | [[Category: Edwards, A M]] | ||
[[Category: | [[Category: Rae, A]] | ||
[[Category: Rankin, S]] | |||
[[Category: Williams, E P]] | |||
[[Category: Bmp]] | |||
[[Category: Inhibitor]] | |||
[[Category: Kinase]] | |||
[[Category: Signaling protein]] | |||
[[Category: Signalling]] | |||