Proteopedia

Phospholipase A2: Difference between revisions

← Older editNewer edit →
No edit summary
Michal Harel (talk | contribs)
31,761 edits
No edit summary
Line 58: Line 58:


Removing the labels, atropine can be seen making contact with the atoms emphasized by the space filling model, interacting with the <scene name='Sandbox_53/Phospholipase2a_interactions/1'>active site</scene> of phospholipase 2A through white as-tricks.
Removing the labels, atropine can be seen making contact with the atoms emphasized by the space filling model, interacting with the <scene name='Sandbox_53/Phospholipase2a_interactions/1'>active site</scene> of phospholipase 2A through white as-tricks.
== 3D Structures of Phospholipase A2 ==
[[Phospholipase A2 3D structures]]
</StructureSection>
</StructureSection>


Line 67: Line 71:
*Phospholipase A2  
*Phospholipase A2  


**[[1ayp]], [[1bbc]], [[1pod]] – hPLA2 – human<br />
**[[1rlw]] – hPLA2 CALB domain<br />
**[[1une]], [[1mkt]], [[1irb]], [[1bp2]], [[1bpq]], [[1g4i]], [[2bp2]], [[2bpp]] - bPLA2 – bovine<br />
**[[1une]], [[1mkt]], [[1irb]], [[1bp2]], [[1bpq]], [[1g4i]], [[2bp2]], [[2bpp]] - bPLA2 – bovine<br />
**[[2zp3]], [[2zp4]], [[2zp5]], [[1c74]], [[1kvw]], [[1kvx]], [[1kvy]], [[1ceh]], [[1mks]], [[1mku]], [[1vkq]], [[1vl9]], [[2bax]], [[2bch]], [[2bd1]], [[1o3w]], [[1gh4]] – bPLA2 (mutant) – bovine<br />
**[[2zp3]], [[2zp4]], [[2zp5]], [[1c74]], [[1kvw]], [[1kvx]], [[1kvy]], [[1ceh]], [[1mks]], [[1mku]], [[1vkq]], [[1vl9]], [[2bax]], [[2bch]], [[2bd1]], [[1o3w]], [[1gh4]] – bPLA2 (mutant) <br />
**[[1bvm]] – bPLA2 - NMR<br />
**[[1bvm]] – bPLA2 - NMR<br />
**[[1p2p]], [[4p2p]] – pPLA2 - pig<br />
**[[1y6p]], [[2phi]], [[3p2p]]  – pPLA2 (mutant) – pig<br />
**[[1sfv]], [[1sfw]], [[1pir]], [[1pis]] – pPLA2 - NMR<br />
**[[1qll]], [[2q2j]] – PLA2 – ''Bothrops pirajai''<br />
**[[1qll]], [[2q2j]] – PLA2 – ''Bothrops pirajai''<br />
**[[2qog]] – PLA2 – ''Crotalus durissus''<br />
**[[2qog]] – PLA2 – ''Crotalus durissus''<br />
Line 77: Line 86:
**[[2osn]], [[1fe5]], [[1dpy]] – kPLA2 – krait<br />
**[[2osn]], [[1fe5]], [[1dpy]] – kPLA2 – krait<br />
**[[1g0z]], [[1g2x]] – kPLA2 (mutant)<br />
**[[1g0z]], [[1g2x]] – kPLA2 (mutant)<br />
**[[2wg7]], [[2wg8]] – rPLA2 – rice<br />
**[[1p2p]], [[4p2p]] – pPLA2 - pig<br />
**[[1y6p]], [[2phi]], [[3p2p]]  – pPLA2 (mutant) – pig<br />
**[[1sfv]], [[1sfw]], [[1pir]], [[1pis]] – pPLA2 - NMR<br />
**[[1yxh]] – NsPLA2 – ''Naja sagittifera''<br />  
**[[1yxh]] – NsPLA2 – ''Naja sagittifera''<br />  
**[[1oz6]], [[2qhe]] – PLA2 – ''Echis carinatus''<br />
**[[1oz6]], [[2qhe]] – PLA2 – ''Echis carinatus''<br />
**[[1it4]], [[1it5]] – PLA2 – Stretomyces violaceoruber – NMR<br />
**[[1mg6]] – PLA2 – ''Agkistrodon acutus''<br />
**[[1mg6]] – PLA2 – ''Agkistrodon acutus''<br />
**[[1s8g]], [[1s8h]], [[1s8i]] – PLA2 – copperhead<br />
**[[1s8g]], [[1s8h]], [[1s8i]] – PLA2 – copperhead<br />
Line 97: Line 101:
**[[1aok]], [[1jlt]], [[1q5t]], [[1rgb]], [[3dih]], [[3g8g]], [[3g8h]] – PLA2 – ''Vipera ammodytes''<br />
**[[1aok]], [[1jlt]], [[1q5t]], [[1rgb]], [[3dih]], [[3g8g]], [[3g8h]] – PLA2 – ''Vipera ammodytes''<br />
**[[2i0u]] – PLA2 – ''Vipera nikolskii''<br />
**[[2i0u]] – PLA2 – ''Vipera nikolskii''<br />
**[[1ayp]], [[1bbc]], [[1pod]] – hPLA2 – human<br />
**[[1rlw]] – hPLA2 CALB domain<br />
**[[1faz]], [[1kp4]] – PLA2 – ''Streptomyces violaceruber''<br />
**[[1god]] – PLA2 – ''Cerrophidion godmani''<br />
**[[1god]] – PLA2 – ''Cerrophidion godmani''<br />
**[[1gp7]], [[1m8t]] – PLA2 – ''Ophiophagus hanna''<br />
**[[1gp7]], [[1m8t]] – PLA2 – ''Ophiophagus hanna''<br />
Line 108: Line 109:
**[[2aoz]] – PLA2 – ''Atropoides nummifer''<br />
**[[2aoz]] – PLA2 – ''Atropoides nummifer''<br />
**[[3v9m]] – PLA2 – king brown snake<br />
**[[3v9m]] – PLA2 – king brown snake<br />
**[[2wg7]], [[2wg8]] – rPLA2 – rice<br />
**[[1faz]], [[1kp4]] – SvPLA2 – ''Streptomyces violaceruber''<br />
**[[1it4]], [[1it5]] – SvPLA2 – NMR<br />


*Phospholipase A2  group I
*Phospholipase A2  group I


**[[3elo]] – hPLA2G1B<br />
**[[3elo]] – hPLA2G1B<br />
**[[3q4y]] - PLA2G1 - Andaman cobra <br />
**[[3fvi]], [[3fvj]] – pPLA2G1B+octyl sulfate<br />
**[[3fvi]], [[3fvj]] – pPLA2G1B+octyl sulfate<br />
**[[3qlm]] - pPLA2G1B + hexadecanoic acid<br />
**[[3qlm]] - pPLA2G1B + hexadecanoic acid<br />
Line 118: Line 121:
**[[4g5i]] – pPLA2 + DBP<br />
**[[4g5i]] – pPLA2 + DBP<br />
**[[4o1y]] – pPLA2 + naphthalene acetic acid<br />
**[[4o1y]] – pPLA2 + naphthalene acetic acid<br />
**[[3q4y]] - PLA2G1 - Andaman cobra <br />
**[[3osh]] – NnPLA2G1+atropine
**[[3osh]] – NnPLA2G1+atropine


Line 124: Line 128:
**[[1j1a]], [[3u8b]] – hPLA2G2A<br />
**[[1j1a]], [[3u8b]] – hPLA2G2A<br />
**[[1n28]], [[1n29]] – hPLA2G2A (mutant)<br />
**[[1n28]], [[1n29]] – hPLA2G2A (mutant)<br />
**[[1cl5]], [[1fb2]], [[1vip]], [[2pvt]], [[2pyc]], [[5vet]] – DrPLA2 – ''Daboia russellii''<br />
**[[2qhw]] – DrPLA2 + gramine derivative<br />
**[[2que]] – DrPLA2 + ajamaline + anisic acid<br />
**[[1kqu]], [[1kvo]] – hPLA2G2A+substrate analog<br />
**[[1kqu]], [[1kvo]] – hPLA2G2A+substrate analog<br />
**[[3u8d]], [[3u8h]], [[3u8i]], [[4hmb]] - hPLA2G2A + inhibitor<br />
**[[3u8d]], [[3u8h]], [[3u8i]], [[4hmb]] - hPLA2G2A + inhibitor<br />
Line 132: Line 133:
**[[5wzw]], [[5wzv]], [[5wzu]], [[5wzt]], [[5wzs]], [[5wzo]], [[5wzm]] - hPLA2G2E + inhibitor<br />
**[[5wzw]], [[5wzv]], [[5wzu]], [[5wzt]], [[5wzs]], [[5wzo]], [[5wzm]] - hPLA2G2E + inhibitor<br />
**[[5yse]] - hPLA2G2E (mutant) + inhibitor<br />
**[[5yse]] - hPLA2G2E (mutant) + inhibitor<br />
**[[3mlm]] – PLA2G2 + myristic acid – ''Neuwiedi lancehead''<br />
**[[1cl5]], [[1fb2]], [[1vip]], [[2pvt]], [[2pyc]], [[5vet]] – DrPLA2 – ''Daboia russellii''<br />
**[[2qhw]] – DrPLA2 + gramine derivative<br />
**[[2que]] – DrPLA2 + ajamaline + anisic acid<br />
**[[4fga]], [[4gfy]], [[4gld]] – DrPLA2 + polypeptide<br />
**[[3g8f]] – DrPLA2G2+polypeptide<br />
**[[3g8f]] – DrPLA2G2+polypeptide<br />
**[[3mlm]] – PLA2G2 + myristic acid – ''Neuwiedi lancehead''<br />
**[[4fga]], [[4gfy]], [[4gld]] – DrPLA2 + polypeptide


*Human PLA2 group IVd
*Human PLA2 group IVd
Line 167: Line 171:
*Phospholipase A2 +inhibitor  
*Phospholipase A2 +inhibitor  


**[[3o4m]], [[3hsw]] – PLA2+inhibitor <br />
**[[1db4]], [[1db5]], [[1dcy]] – hPLA2+indole<br />
**[[1poe]] – hPLA2+phosphonyl inhibitor<br />
**[[1fdk]] – bPLA2+MJ33<br />
**[[1mkv]] – bPLA2+transition state analog<br />
**[[1o2e]] – bPLA2 (mutant)+anisic acid<br />
**[[2b96]] - bPLA2+benzoic acid derivative<br />
**[[3bp2]] – bPLA2+pyruvic acid<br />
**[[3o4m]], [[3hsw]] – pPLA2+inhibitor <br />
**[[2azy]], [[2azz]], [[2b00]], [[2b01]], [[2b03]], [[2b04]]  – pPLA2+cholate derivative<br />
**[[2azy]], [[2azz]], [[2b00]], [[2b01]], [[2b03]], [[2b04]]  – pPLA2+cholate derivative<br />
**[[1y6o]], [[1fx9]], [[1fxf]] – pPLA2+MJ33<br />
**[[1y6o]], [[1fx9]], [[1fxf]] – pPLA2+MJ33<br />
Line 187: Line 198:
**[[1oxr]] – NsPLA2+aspirin<br />
**[[1oxr]] – NsPLA2+aspirin<br />
**[[1bk9]] – AhPLA2+PBPB<br />
**[[1bk9]] – AhPLA2+PBPB<br />
**[[1fdk]] – bPLA2+MJ33<br />
**[[1mkv]] – bPLA2+transition state analog<br />
**[[1o2e]] – bPLA2 (mutant)+anisic acid<br />
**[[2b96]] - bPLA2+benzoic acid derivative<br />
**[[3bp2]] – bPLA2+pyruvic acid<br />
**[[1pob]] - NnPLA2+transition state analog<br />
**[[1pob]] - NnPLA2+transition state analog<br />
**[[1poc]] - PLA2+transition state analog – Honey bee<br />
**[[1poc]] - PLA2+transition state analog – Honey bee<br />
**[[1db4]], [[1db5]], [[1dcy]] – hPLA2+indole<br />
**[[1poe]] – hPLA2+phosphonyl inhibitor<br />
**[[1fv0]] – DrPLA2+aristolochic acid<br />
**[[1fv0]] – DrPLA2+aristolochic acid<br />
**[[1sv3]] - DrPLA2+benzoic acid derivative<br />
**[[1sv3]] - DrPLA2+benzoic acid derivative<br />
Line 233: Line 237:
*Lp-PLA2  
*Lp-PLA2  


**[[3d59]] – hLP-PLA2 residues 47-429 <br />
**[[1wab]] – bLP-PLA2 + acetate <br />
**[[1wab]] – bLP-PLA2 + acetate <br />
**[[1bwp]], 1bwq]], 1bwr]], 1es9]] – bLP-PLA2 ( mutant) <br />
**[[1bwp]], 1bwq]], 1bwr]], 1es9]] – bLP-PLA2 ( mutant) <br />
Line 238: Line 243:
**[[1uuj]] - mLP-PLA2 α subunit N terminal – mouse<br />
**[[1uuj]] - mLP-PLA2 α subunit N terminal – mouse<br />
**[[1vyh]] - mLP-PLA2 α subunit C terminal + β subunit<br />
**[[1vyh]] - mLP-PLA2 α subunit C terminal + β subunit<br />
**[[3d59]] – hLP-PLA2 residues 47-429 <br />
   
   
*Lp-PLA2 binary complexes
*Lp-PLA2 binary complexes
   
   
**[[3dt6]] - bLP-PLA2 α subunit (mutant) + paraoxon<br />
**[[3dt8]] - bLP-PLA2 α subunit (mutant) + sarin<br />
**[[3dt9]] - bLP-PLA2 α subunit (mutant) + soman<br />
**[[3dt9]] - bLP-PLA2 α subunit (mutant) + soman<br />
**[[3d5e]] - hLP-PLA2 residues 47-429 + paraoxon<br />
**[[3d5e]] - hLP-PLA2 residues 47-429 + paraoxon<br />
Line 252: Line 254:
**[[5i8p]], [[5i9i]], [[5jad]], [[5jah]], [[5jal]], [[5jan]], [[5jao]], [[5jap]], [[5jar]], [[5jas]], [[5jat]], [[5jau]], [[5lp1]], [[5lz2]], [[5lz8]], [[5lz9]] - hLP-PLA2 residues 47-429 + inhibitor<br />
**[[5i8p]], [[5i9i]], [[5jad]], [[5jah]], [[5jal]], [[5jan]], [[5jao]], [[5jap]], [[5jar]], [[5jas]], [[5jat]], [[5jau]], [[5lp1]], [[5lz2]], [[5lz8]], [[5lz9]] - hLP-PLA2 residues 47-429 + inhibitor<br />
**[[5lyy]], [[5lz4]], [[5lz5]], [[5lz7]] - hLP-PLA2 residues 47-429 (mutant) + inhibitor<br />
**[[5lyy]], [[5lz4]], [[5lz5]], [[5lz7]] - hLP-PLA2 residues 47-429 (mutant) + inhibitor<br />
**[[3dt6]] - bLP-PLA2 α subunit (mutant) + paraoxon<br />
**[[3dt8]] - bLP-PLA2 α subunit (mutant) + sarin<br />
**[[3dt9]] - bLP-PLA2 α subunit (mutant) + soman<br />


*Bothrops toxins  
*Bothrops toxins  
Line 275: Line 280:
*Pro-Phospholipase A2
*Pro-Phospholipase A2


**[[4bp2]] – bPPLA2<br />
**[[1hn4]] – pPPLA2+MJ33<br />
**[[1hn4]] – pPPLA2+MJ33<br />
**[[4bp2]] – bPPLA2
 
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky, Joel L. Sussman
Retrieved from "https://proteopedia.openfox.io/w/Phospholipase_A2"