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==CRYSTAL STRUCTURE OF ACTINOMYCIN D== | ==CRYSTAL STRUCTURE OF ACTINOMYCIN D== | ||
<StructureSection load='1a7y' size='340' side='right' caption='[[1a7y]], [[Resolution|resolution]] 0.94Å' scene=''> | <StructureSection load='1a7y' size='340' side='right'caption='[[1a7y]], [[Resolution|resolution]] 0.94Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1a7y]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_antibioticus Streptomyces antibioticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A7Y FirstGlance]. <br> | <table><tr><td colspan='2'>[[1a7y]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_antibioticus Streptomyces antibioticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A7Y FirstGlance]. <br> | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a7y OCA], [http://pdbe.org/1a7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a7y RCSB], [http://www.ebi.ac.uk/pdbsum/1a7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1a7y ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a7y OCA], [http://pdbe.org/1a7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a7y RCSB], [http://www.ebi.ac.uk/pdbsum/1a7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1a7y ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Untwinned single crystals of the actinomycins D and Z3 that diffracted to atomic resolution could be obtained for the first time. Low-temperature data collection and a new ab initio method for solving the structures led to precise crystal structures which showed, for example, that the unit cell of actinomycin D contains three molecules, two of which are present in the form of a hydrogen-bridged dimer related by a pseudo-twofold axis (see picture). | |||
Crystal Structures of Actinomycin D and Actinomycin Z3.,Schafer M, Sheldrick GM, Bahner I, Lackner H Angew Chem Int Ed Engl. 1998 Sep 18;37(17):2381-2384. doi:, 10.1002/(SICI)1521-3773(19980918)37:17<2381::AID-ANIE2381>3.0.CO;2-L. PMID:29710967<ref>PMID:29710967</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1a7y" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Streptomyces antibioticus]] | [[Category: Streptomyces antibioticus]] | ||
[[Category: Bahner, I]] | [[Category: Bahner, I]] | ||
Revision as of 14:17, 13 November 2019
CRYSTAL STRUCTURE OF ACTINOMYCIN DCRYSTAL STRUCTURE OF ACTINOMYCIN D
Structural highlights
Publication Abstract from PubMedUntwinned single crystals of the actinomycins D and Z3 that diffracted to atomic resolution could be obtained for the first time. Low-temperature data collection and a new ab initio method for solving the structures led to precise crystal structures which showed, for example, that the unit cell of actinomycin D contains three molecules, two of which are present in the form of a hydrogen-bridged dimer related by a pseudo-twofold axis (see picture). Crystal Structures of Actinomycin D and Actinomycin Z3.,Schafer M, Sheldrick GM, Bahner I, Lackner H Angew Chem Int Ed Engl. 1998 Sep 18;37(17):2381-2384. doi:, 10.1002/(SICI)1521-3773(19980918)37:17<2381::AID-ANIE2381>3.0.CO;2-L. PMID:29710967[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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