6ddi: Difference between revisions

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-'''Unreleased structure'''
-The entry 6ddi is ON HOLD  until Paper Publication
+==Crystal Structure of the human BRD2 BD1 bromodomain in complex with a Tetrahydroquinoline analogue==
+<StructureSection load='6ddi' size='340' side='right'caption='[[6ddi]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ddi]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DDI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DDI FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=03S:METHANESULFONIC+ACID'>03S</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G7V:4-{[(2S,4R)-1-acetyl-2-methyl-6-(1H-pyrazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]amino}benzonitrile'>G7V</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ddi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ddi OCA], [http://pdbe.org/6ddi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ddi RCSB], [http://www.ebi.ac.uk/pdbsum/6ddi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ddi ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: White, S W]]
+[[Category: Yun, M]]
+[[Category: Bet]]
+[[Category: Brd2]]
+[[Category: Bromodomain]]
+[[Category: Complex]]
+[[Category: Inhibitor]]
+[[Category: Transcription]]
+[[Category: Transcription-inhibitor complex]]