Nucleoporin: Difference between revisions
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== Disease == | == Disease == | ||
NUP98 and NUP214 gene translocation is associated with myeloid and lymphoid malignancies. NUP88 is over expressed in ovarian tumors. NUP214 is the functional receptor of adenovirus 2 nucleocapsids<ref>PMID:14693424</ref>. | NUP98 and NUP214 gene translocation is associated with myeloid and lymphoid malignancies. NUP88 is over expressed in ovarian tumors. NUP214 is the functional receptor of adenovirus 2 nucleocapsids<ref>PMID:14693424</ref>. | ||
== 3D Structures of Nucleoporin == | |||
[[Nucleoporin 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of Nucleoporin == | == 3D Structures of Nucleoporin == | ||
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**[[4fhm]], [[4fhn]], [[4gq2]] - fyNUP37 + NUP120<br /> | **[[4fhm]], [[4fhn]], [[4gq2]] - fyNUP37 + NUP120<br /> | ||
*NUP43 | *NUP43 | ||
**[[4i79]] – hNUP43 + polypeptide<br /> | **[[4i79]] – hNUP43 + polypeptide - human<br /> | ||
*NUP50 | *NUP50 | ||
**[[2ec1]] – hNUP50 RANBD - | **[[2ec1]] – hNUP50 RANBD <br /> | ||
**[[3tj3]] - hNUP50 NTD+importin<br /> | |||
**[[2c1m]] – mNUP50 NTD +importin <br /> | **[[2c1m]] – mNUP50 NTD +importin <br /> | ||
*NUP53 | *NUP53 | ||
**[[3p3d]] - NUP53 RRM domain - ''Pischia guillermondii''<br /> | **[[3p3d]] - NUP53 RRM domain - ''Pischia guillermondii''<br /> | ||
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**[[5hb3]] – CtNUP53 + NUP NIC96 <br /> | **[[5hb3]] – CtNUP53 + NUP NIC96 <br /> | ||
*NUP54 | *NUP54 | ||
**[[4jo7]], [[4jo9]] – hNUP54 + hNUP58/45 <br /> | |||
**[[3t97]] – rNUP54 + NUP62 - rat<br /> | **[[3t97]] – rNUP54 + NUP62 - rat<br /> | ||
**[[4j3h]] – rNUP54 (mutant)<br /> | **[[4j3h]] – rNUP54 (mutant)<br /> | ||
**[[3t98]] – rNUP54 + rNUP58/45 <br /> | **[[3t98]] – rNUP54 + rNUP58/45 <br /> | ||
**[[ | **[[5c3l]] – fNUP54 coiled coil + NUP58 coiled coil + NUP62 coiled coil + nanobody - frog<br /> | ||
**[[ | **[[5c2u]] – fNUP54 ferredoxin-like domain + nanobody <br /> | ||
*NUP57 | *NUP57 | ||
**[[5cwt]] – CtNUP57 residues 265-317<br /> | **[[5cwt]] – CtNUP57 residues 265-317<br /> | ||
**[[5cws]] – CtNUP57 residues 74-319 + NUP49 + NIC96 + antibody<br /> | **[[5cws]] – CtNUP57 residues 74-319 + NUP49 + NIC96 + antibody<br /> | ||
*NUP58 | *NUP58 | ||
**[[4jq5]] – hNUP58/45 <br /> | |||
**[[2osz]] – rNUP58/45 <br /> | **[[2osz]] – rNUP58/45 <br /> | ||
*NUP62 | *NUP62 | ||
**[[5h1x]] – rNUP62 coiled-coil domain<br /> | **[[5h1x]] – rNUP62 coiled-coil domain<br /> | ||