Nitric Oxide Synthase: Difference between revisions
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Structures used in the section above: [[1tll]] | Structures used in the section above: [[1tll]] | ||
== 3D Structures of Nitric Oxide Synthase == | |||
[[Nitric Oxide Synthase 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of Nitric Oxide Synthase == | == 3D Structures of Nitric Oxide Synthase == | ||
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*Endothelial NOS | *Endothelial NOS | ||
**[[3eah]] – h-eNOS OD - human<br /> | |||
**[[3nos]], [[4d1o]] – h-eNOS OD+arginine<br /> | |||
**[[1m9j]] – h-eNOS OD+chlorzoxazone<br /> | |||
**[[1m9k]], [[1m9r]], [[4d1p]], [[6av7]], [[6av6]], [[6nhf]], [[6nh8]], [[6nh7]], [[6nh6]], [[6nh5]], [[6nh4]], [[6nh3]], [[6nh2]], [[6nh1]], [[6cif]], [[6cie]] – h-eNOS OD+ inhibitor<br /> | |||
**[[1nsi]] - h-eNOS OD+ Zn<br /> | |||
**[[3nld]], [[3nle]], [[3nlf]], [[3nlg]], [[3jww]], [[3jwx]], [[3jwy]], [[3jwz]], [[3dqs]], [[3dqt]], [[3pnh]], [[4luw]] – b-eNOS OD+pyrrolidinomethyl pyridine derivative – bovine<br /> | **[[3nld]], [[3nle]], [[3nlf]], [[3nlg]], [[3jww]], [[3jwx]], [[3jwy]], [[3jwz]], [[3dqs]], [[3dqt]], [[3pnh]], [[4luw]] – b-eNOS OD+pyrrolidinomethyl pyridine derivative – bovine<br /> | ||
**[[1dm6]] – b-eNOS OD+guanidine derivative<br /> | **[[1dm6]] – b-eNOS OD+guanidine derivative<br /> | ||
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**[[4jsk]], [[4jsl]], [[4jsm]], [[4imx]], [[4k5h]], [[4k5i]], [[4k5j]], [[4k5k]], [[4c3a]] – r-eNOS OD+ pyridine derivative<br /> | **[[4jsk]], [[4jsl]], [[4jsm]], [[4imx]], [[4k5h]], [[4k5i]], [[4k5j]], [[4k5k]], [[4c3a]] – r-eNOS OD+ pyridine derivative<br /> | ||
**[[4kcp]], [[4kcq]], [[4kcr]], [[4kcs]] - r-eNOS OD heme domain +thiophene carboximidamide derivative<br /> | **[[4kcp]], [[4kcq]], [[4kcr]], [[4kcs]] - r-eNOS OD heme domain +thiophene carboximidamide derivative<br /> | ||
*Neuronal NOS | *Neuronal NOS | ||
**[[4uh5]], [[6av5]], [[6av4]], [[6av3]] - h-nNOS heme domain +inhibitor<br /> | |||
**[[4uh6]], [[4uch]], [[6av2]], [[6av1]], [[6av0]], [[6auz]], [[6auy]], [[5vv4]], [[5vv2]], [[5vv1]], [[5vuz]], [[5vuy]], [[5vux]], [[5vuw]], [[5vuv]], [[6nhb]], [[6nhc]], [[6cid]], [[6ng8]], [[6ngi]], [[6ngh]], [[6ngf]], [[6nge]], [[6ngd]], [[6ngc]], [[6ngb]], [[6nga]], [[6ng7]], [[6ng6]], [[6ng5]], [[6ng4]], [[6ng2]], [[6ng1]], [[6cic]] - h-nNOS heme domain + inhibitor<br /> | |||
**[[4d1n]] - h-nNOS heme domain (mutant) + arginine<br /> | |||
**[[2hx2]] – b-nNOS OD+nitroguanidine derivative<br /> | **[[2hx2]] – b-nNOS OD+nitroguanidine derivative<br /> | ||
**[[3nlv]], [[3nlw]], [[3nlx]], [[3nly]], [[3nlz]], [[3nm0]], [[4uh7]], [[4uh8]], [[4uh9]], [[4uha]] - b-nNOS OD + inhibitor<br /> | **[[3nlv]], [[3nlw]], [[3nlx]], [[3nly]], [[3nlz]], [[3nm0]], [[4uh7]], [[4uh8]], [[4uh9]], [[4uha]] - b-nNOS OD + inhibitor<br /> | ||
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**[[1qau]] - r-nNOS OD PDZ domain<br /> | **[[1qau]] - r-nNOS OD PDZ domain<br /> | ||
**[[1qav]], [[4hop]] - r-nNOS OD PDZ domain + α-1 syntrophin<br /> | **[[1qav]], [[4hop]] - r-nNOS OD PDZ domain + α-1 syntrophin<br /> | ||
**[[1qwc]], [[3q99]], [[3q9a]], [[1mmv]], [[1mmw]], [[3dqr]], [[3ufo]], [[3ufp]], [[3ufq]], [[3ufr]], [[3ufs]], [[3uft]], [[3ufu]], [[3ufv]], [[3ufw]], [[4eux]], [[5vui]], [[4upm]], [[4upn]], [[4upo]], [[4upp]], [[5vuk]], [[5vul]], [[5vum]], [[5vun]], [[5vuo]], [[5vup]], [[5vuq]], [[5vur]], [[5vus]], [[5vut]], [[5vuu]], [[5unr]], [[5unt]], [[5unu]], [[5unv]], [[5unw]], [[5unx]], [[5uny]], [[5unz]], [[5uo0]], [[5fw0]], [[5fvo]], [[5fvp]], [[5fvq]], [[5fvr]], [[5fvs]], [[5fvt]], [[5agk]], [[5agl]], [[5agm]], [[5agn]], [[5ago]], [[5agp]], [[4v3v]], [[4v3w]], [[4v3x]], [[4v3y]], [[4v3z]], [[5ad4]], [[5ad5]], [[5ad6]], [[5ad7]], [[5ad8]], [[5ad9]], [[5ada]], [[5adb]], [[5adc]], [[4ugz]], [[4d33]], [[4d34]], [[4d35]], [[4d2y]], [[4d1z]], [[4d30]], [[4d31]], [[4uh4]], [[4d7o]], [[4d3b]], [[4d32]], [[4ctp]], [[4ctq]], [[4ctr]], [[4ctt]], [[4ctu]], [[4ctv]], [[4c39]], [[6aux]], [[6auw]], [[6auv]], [[6auu]], [[6aut]], [[6aur]], [[6auq]], [[5vuj]], [[4uh3]], [[4uh2]], [[4uh1]], [[4uh0]], [[4d2z]], [[4ctx]], [[4ctw]] – r-nNOS OD+inhibitor<br /> | **[[1qwc]], [[3q99]], [[3q9a]], [[1mmv]], [[1mmw]], [[3dqr]], [[3ufo]], [[3ufp]], [[3ufq]], [[3ufr]], [[3ufs]], [[3uft]], [[3ufu]], [[3ufv]], [[3ufw]], [[4eux]], [[5vui]], [[4upm]], [[4upn]], [[4upo]], [[4upp]], [[5vuk]], [[5vul]], [[5vum]], [[5vun]], [[5vuo]], [[5vup]], [[5vuq]], [[5vur]], [[5vus]], [[5vut]], [[5vuu]], [[5unr]], [[5unt]], [[5unu]], [[5unv]], [[5unw]], [[5unx]], [[5uny]], [[5unz]], [[5uo0]], [[5fw0]], [[5fvo]], [[5fvp]], [[5fvq]], [[5fvr]], [[5fvs]], [[5fvt]], [[5agk]], [[5agl]], [[5agm]], [[5agn]], [[5ago]], [[5agp]], [[4v3v]], [[4v3w]], [[4v3x]], [[4v3y]], [[4v3z]], [[5ad4]], [[5ad5]], [[5ad6]], [[5ad7]], [[5ad8]], [[5ad9]], [[5ada]], [[5adb]], [[5adc]], [[4ugz]], [[4d33]], [[4d34]], [[4d35]], [[4d2y]], [[4d1z]], [[4d30]], [[4d31]], [[4uh4]], [[4d7o]], [[4d3b]], [[4d32]], [[4ctp]], [[4ctq]], [[4ctr]], [[4ctt]], [[4ctu]], [[4ctv]], [[4c39]], [[6aux]], [[6auw]], [[6auv]], [[6auu]], [[6aut]], [[6aur]], [[6auq]], [[5vuj]], [[4uh3]], [[4uh2]], [[4uh1]], [[4uh0]], [[4d2z]], [[4ctx]], [[4ctw]], [[6nhe]], [[6nhd]], [[6nh0]], [[6ngz]], [[6ngy]], [[6ngx]], [[6ngw]], [[6ngv]], [[6ngu]], [[6ngt]], [[6ngs]], [[6ngr]], [[6ngq]], [[6ngp]], [[6ngn]], [[6ngm]], [[6ngl]], [[6ngk]], [[6ngj]] – r-nNOS OD+inhibitor<br /> | ||
**[[5vv0]], [[5vv3]], [[5vv5]], [[5uns]], [[5uo1]], [[5uo2]], [[5uo3]], [[5uo4]], [[5uo5]], [[5uo6]], [[5uo7]], [[5g0n]], [[5g0p]], [[5fvu]], [[5fvv]], [[5fvx]], [[5fvw]], [[5fvx]], [[4v3u]], [[5add]], [[5ade]], [[5adf]], [[5adg]], [[5adi]], [[4cx3]], [[4cx4]], [[4cx5]], [[4cx6]], [[6aus]], [[5g0o]] – r-nNOS OD (mutant) +inhibitor<br /> | **[[5vv0]], [[5vv3]], [[5vv5]], [[5uns]], [[5uo1]], [[5uo2]], [[5uo3]], [[5uo4]], [[5uo5]], [[5uo6]], [[5uo7]], [[5g0n]], [[5g0p]], [[5fvu]], [[5fvv]], [[5fvx]], [[5fvw]], [[5fvx]], [[4v3u]], [[5add]], [[5ade]], [[5adf]], [[5adg]], [[5adi]], [[4cx3]], [[4cx4]], [[4cx5]], [[4cx6]], [[6aus]], [[5g0o]] – r-nNOS OD (mutant) +inhibitor<br /> | ||
**[[3jt3]], [[3jt4]], [[3jt5]], [[3jt6]], [[3jt7]], [[3jt8]], [[3jt9]], [[3jta]] – r-nNOS OD+ornithine derivative<br /> | **[[3jt3]], [[3jt4]], [[3jt5]], [[3jt6]], [[3jt7]], [[3jt8]], [[3jt9]], [[3jta]] – r-nNOS OD+ornithine derivative<br /> | ||
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**[[1f20]] - r-nNOS FAD/NADP domain<br /> | **[[1f20]] - r-nNOS FAD/NADP domain<br /> | ||
**[[1vag]] – m-nNOS OD+inhibitor - mouse<br /> | **[[1vag]] – m-nNOS OD+inhibitor - mouse<br /> | ||
*Inducible NOS | *Inducible NOS | ||
**[[3hr4]] – h-iNOS residues 503-715+calmodulin <br /> | |||
**[[3e7g]] – h-iNOS residues 82-505+inhibitor<br /> | |||
**[[3ej8]] – h-iNOS OD+imidazole<br /> | |||
**[[4nos]], [[4cx7]] – h-iNOS OD+inhibitor<br /> | |||
**[[1nsi]] – h-iNOS OD+arginine<br /> | |||
**[[2nsi]] – h-iNOS OD+thiourea derivative<br /> | |||
**[[3nqs]], [[3e65]], [[3eai]], [[3ebd]], [[3ebf]], [[1r35]], [[2nod]] – m-iNOS OD + pterin derivative<br /> | **[[3nqs]], [[3e65]], [[3eai]], [[3ebd]], [[3ebf]], [[1r35]], [[2nod]] – m-iNOS OD + pterin derivative<br /> | ||
**[[1jwj]], [[1jwk]] – m-iNOS OD (mutant)+ pterin derivative<br /> | **[[1jwj]], [[1jwk]] – m-iNOS OD (mutant)+ pterin derivative<br /> | ||
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**[[1jwj]] – m-iNOS OD + inhibitor<br /> | **[[1jwj]] – m-iNOS OD + inhibitor<br /> | ||
**[[1jwk]] - m-iNOS OD (mutant) + inhibitor<br /> | **[[1jwk]] - m-iNOS OD (mutant) + inhibitor<br /> | ||
**[[3gof]] - c-iNOS OD + calmodulin – chicken<br /> | **[[3gof]] - c-iNOS OD + calmodulin – chicken<br /> | ||