1dde: Difference between revisions
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==STRUCTURE OF THE DNAG CATALYTIC CORE== | ==STRUCTURE OF THE DNAG CATALYTIC CORE== | ||
<StructureSection load='1dde' size='340' side='right' caption='[[1dde]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='1dde' size='340' side='right'caption='[[1dde]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1dde]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DDE FirstGlance]. <br> | <table><tr><td colspan='2'>[[1dde]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DDE FirstGlance]. <br> | ||
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</div> | </div> | ||
<div class="pdbe-citations 1dde" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1dde" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[RNA polymerase|RNA polymerase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bacillus coli migula 1895]] | [[Category: Bacillus coli migula 1895]] | ||
[[Category: Large Structures]] | |||
[[Category: Berger, J M]] | [[Category: Berger, J M]] | ||
[[Category: Keck, J L]] | [[Category: Keck, J L]] | ||
Revision as of 12:22, 6 November 2019
STRUCTURE OF THE DNAG CATALYTIC CORESTRUCTURE OF THE DNAG CATALYTIC CORE
Structural highlights
Function[PRIM_ECOLI] DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedAll cellular organisms use specialized RNA polymerases called "primases" to synthesize RNA primers for the initiation of DNA replication. The high-resolution crystal structure of a primase, comprising the catalytic core of the Escherichia coli DnaG protein, was determined. The core structure contains an active-site architecture that is unrelated to other DNA or RNA polymerase palm folds, but is instead related to the "toprim" fold. On the basis of the structure, it is likely that DnaG binds nucleic acid in a groove clustered with invariant residues and that DnaG is positioned within the replisome to accept single-stranded DNA directly from the replicative helicase. Structure of the RNA polymerase domain of E. coli primase.,Keck JL, Roche DD, Lynch AS, Berger JM Science. 2000 Mar 31;287(5462):2482-6. PMID:10741967[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences |
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