6itb: Difference between revisions
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<StructureSection load='6itb' size='340' side='right'caption='[[6itb]], [[Resolution|resolution]] 4.70Å' scene=''> | <StructureSection load='6itb' size='340' side='right'caption='[[6itb]], [[Resolution|resolution]] 4.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6itb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ITB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ITB FirstGlance]. <br> | <table><tr><td colspan='2'>[[6itb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Fhv Fhv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ITB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ITB FirstGlance]. <br> | ||
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nodavirus_endopeptidase Nodavirus endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.44 3.4.23.44] </span></td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">alpha ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12287 FHV])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nodavirus_endopeptidase Nodavirus endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.44 3.4.23.44] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6itb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6itb OCA], [http://pdbe.org/6itb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6itb RCSB], [http://www.ebi.ac.uk/pdbsum/6itb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6itb ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6itb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6itb OCA], [http://pdbe.org/6itb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6itb RCSB], [http://www.ebi.ac.uk/pdbsum/6itb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6itb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Fhv]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Nodavirus endopeptidase]] | [[Category: Nodavirus endopeptidase]] | ||
Revision as of 10:59, 6 November 2019
Icosahedral asymmetric unit (iASU) model of the well-refined part of FHV eluted particleIcosahedral asymmetric unit (iASU) model of the well-refined part of FHV eluted particle
Structural highlights
Function[CAPSD_FHV] Capsid protein alpha self-assembles to form an icosahedral procapsid with a T=3 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins trimers. In addition, 240 calcium ions are incorporated per capsid during assembly. The capsid encapsulates the two genomic RNAs. Capsid maturation occurs via autoproteolytic cleavage of capsid protein alpha generating capsid protein beta and the membrane-active peptide gamma. Peptide gamma: membrane-permeabilizing peptide produced by virus maturation, thereby creating the infectious virion. After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (Probable). |
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