6cl1: Difference between revisions

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==Caspase-7 in complex with Ac-DW3-KE==
==Caspase-7 in complex with Ac-DW3-KE==
<StructureSection load='6cl1' size='340' side='right' caption='[[6cl1]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
<StructureSection load='6cl1' size='340' side='right'caption='[[6cl1]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6cl1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CL1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6cl1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CL1 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=1MH:3-PYRIDIN-3-YL-L-ALANINE'>1MH</scene>, <scene name='pdbligand=1U8:(3S)-3-AMINO-5-[(2,6-DIMETHYLBENZOYL)OXY]-4-OXOPENTANOIC+ACID'>1U8</scene>, <scene name='pdbligand=B3L:(3S)-3-AMINO-5-METHYLHEXANOIC+ACID'>B3L</scene></td></tr>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=1MH:3-PYRIDIN-3-YL-L-ALANINE'>1MH</scene>, <scene name='pdbligand=1U8:(3S)-3-AMINO-5-[(2,6-DIMETHYLBENZOYL)OXY]-4-OXOPENTANOIC+ACID'>1U8</scene>, <scene name='pdbligand=B3L:(3S)-3-AMINO-5-METHYLHEXANOIC+ACID'>B3L</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP7, MCH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cl1 OCA], [http://pdbe.org/6cl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cl1 RCSB], [http://www.ebi.ac.uk/pdbsum/6cl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cl1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cl1 OCA], [http://pdbe.org/6cl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cl1 RCSB], [http://www.ebi.ac.uk/pdbsum/6cl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cl1 ProSAT]</span></td></tr>
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== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.  
[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.  
==See Also==
*[[Caspase 3D structures|Caspase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Caspase-7]]
[[Category: Caspase-7]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Gonzalez-Paez, G E]]
[[Category: Gonzalez-Paez, G E]]
[[Category: Solania, A T]]
[[Category: Solania, A T]]

Revision as of 10:43, 6 November 2019

Caspase-7 in complex with Ac-DW3-KECaspase-7 in complex with Ac-DW3-KE

Structural highlights

6cl1 is a 6 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:, ,
Gene:CASP7, MCH3 (HUMAN)
Activity:Caspase-7, with EC number 3.4.22.60
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

See Also

6cl1, resolution 2.65Å

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