5wtf: Difference between revisions
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==Cryo-EM structure for Hepatitis A virus empty particle== | ==Cryo-EM structure for Hepatitis A virus empty particle== | ||
<StructureSection load='5wtf' size='340' side='right' caption='[[5wtf]], [[Resolution|resolution]] 3.90Å' scene=''> | <StructureSection load='5wtf' size='340' side='right'caption='[[5wtf]], [[Resolution|resolution]] 3.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5wtf]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WTF FirstGlance]. <br> | <table><tr><td colspan='2'>[[5wtf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Hav Hav]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WTF FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wte|5wte]], [[5wth|5wth]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wte|5wte]], [[5wth|5wth]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wtf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wtf OCA], [http://pdbe.org/5wtf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wtf RCSB], [http://www.ebi.ac.uk/pdbsum/5wtf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wtf ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wtf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wtf OCA], [http://pdbe.org/5wtf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wtf RCSB], [http://www.ebi.ac.uk/pdbsum/5wtf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wtf ProSAT]</span></td></tr> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Hav]] | |||
[[Category: Large Structures]] | |||
[[Category: Dang, M]] | [[Category: Dang, M]] | ||
[[Category: Fry, E E]] | [[Category: Fry, E E]] | ||
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[[Category: Zhang, B]] | [[Category: Zhang, B]] | ||
[[Category: Zhu, L]] | [[Category: Zhu, L]] | ||
[[Category: Neutralizing mechanism]] | [[Category: Neutralizing mechanism]] | ||
[[Category: Receptor recognition]] | [[Category: Receptor recognition]] | ||
[[Category: Viral entry]] | [[Category: Viral entry]] | ||
[[Category: Virus]] | [[Category: Virus]] | ||
Revision as of 10:26, 6 November 2019
Cryo-EM structure for Hepatitis A virus empty particleCryo-EM structure for Hepatitis A virus empty particle
Structural highlights
Publication Abstract from PubMedHepatitis A virus (HAV) infects approximately 1.4 million people annually and, although there is a vaccine, there are no licensed therapeutic drugs. HAV is unusually stable (making disinfection problematic) and little is known of how it enters cells and releases its RNA. Here we report a potent HAV-specific monoclonal antibody, R10, which neutralizes HAV infection by blocking attachment to the host cell. High-resolution cryo-EM structures of HAV full and empty particles and of the complex of HAV with R10 Fab reveal the atomic details of antibody binding and point to a receptor recognition site at the pentamer interface. These results, together with our observation that the R10 Fab destabilizes the capsid, suggest the use of a receptor mimic mechanism to neutralize virus infection, providing new opportunities for therapeutic intervention. Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site.,Wang X, Zhu L, Dang M, Hu Z, Gao Q, Yuan S, Sun Y, Zhang B, Ren J, Kotecha A, Walter TS, Wang J, Fry EE, Stuart DI, Rao Z Proc Natl Acad Sci U S A. 2017 Jan 10. pii: 201616502. doi:, 10.1073/pnas.1616502114. PMID:28074040[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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