6qb3: Difference between revisions

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'''Unreleased structure'''


The entry 6qb3 is ON HOLD
==Apo Mcl1 in a complex with a scFv==
 
<StructureSection load='6qb3' size='340' side='right'caption='[[6qb3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
Authors: Kazmirski, S., Hargreaves, D.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6qb3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QB3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QB3 FirstGlance]. <br>
Description: Apo Mcl1 in a complex with a scFv
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qb3 OCA], [http://pdbe.org/6qb3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qb3 RCSB], [http://www.ebi.ac.uk/pdbsum/6qb3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qb3 ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Hargreaves, D]]
[[Category: Kazmirski, S]]
[[Category: Kazmirski, S]]
[[Category: Hargreaves, D]]
[[Category: Apoptosis]]
[[Category: Mcl1-scfv complex]]

Revision as of 09:47, 6 November 2019

Apo Mcl1 in a complex with a scFvApo Mcl1 in a complex with a scFv

Structural highlights

6qb3 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.[1]

References

  1. ↑ Bingle CD, Craig RW, Swales BM, Singleton V, Zhou P, Whyte MK. Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death. J Biol Chem. 2000 Jul 21;275(29):22136-46. PMID:10766760 doi:10.1074/jbc.M909572199

6qb3, resolution 1.90Å

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