1d53: Difference between revisions
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'''CRYSTAL STRUCTURE AT 1.5 ANGSTROMS RESOLUTION OF D(CGCICICG), AN OCTANUCLEOTIDE CONTAINING INOSINE, AND ITS COMPARISON WITH D(CGCG) AND D(CGCGCG) STRUCTURES''' | '''CRYSTAL STRUCTURE AT 1.5 ANGSTROMS RESOLUTION OF D(CGCICICG), AN OCTANUCLEOTIDE CONTAINING INOSINE, AND ITS COMPARISON WITH D(CGCG) AND D(CGCGCG) STRUCTURES''' | ||
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==About this Structure== | ==About this Structure== | ||
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D53 OCA]. | |||
==Reference== | ==Reference== | ||
Crystal structure at 1.5-A resolution of d(CGCICICG), an octanucleotide containing inosine, and its comparison with d(CGCG) and d(CGCGCG) structures., Kumar VD, Harrison RW, Andrews LC, Weber IT, Biochemistry. 1992 Feb 11;31(5):1541-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1737011 1737011] | Crystal structure at 1.5-A resolution of d(CGCICICG), an octanucleotide containing inosine, and its comparison with d(CGCG) and d(CGCGCG) structures., Kumar VD, Harrison RW, Andrews LC, Weber IT, Biochemistry. 1992 Feb 11;31(5):1541-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1737011 1737011] | ||
[[Category: Andrews, L C.]] | [[Category: Andrews, L C.]] | ||
[[Category: Harrison, R W.]] | [[Category: Harrison, R W.]] | ||
[[Category: Kumar, V D.]] | [[Category: Kumar, V D.]] | ||
[[Category: Weber, I T.]] | [[Category: Weber, I T.]] | ||
[[Category: | [[Category: Double helix]] | ||
[[Category: | [[Category: Z-dna]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:52:19 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 13:52, 30 April 2008
CRYSTAL STRUCTURE AT 1.5 ANGSTROMS RESOLUTION OF D(CGCICICG), AN OCTANUCLEOTIDE CONTAINING INOSINE, AND ITS COMPARISON WITH D(CGCG) AND D(CGCGCG) STRUCTURES
OverviewOverview
The octadeoxyribonucleotide d(CGCICICG) has been crystallized in space group P(6)5(22) with unit cell dimensions of a = b = 31.0 A and c = 43.7 A, and X-ray diffraction data have been collected to 1.5-A resolution. Precession photographs and the self-Patterson function indicate that 12 base pairs of Z-conformation DNA stack along the c-axis, and the double helices pack in a hexagonal array similar to that seen in other crystals of Z-DNA. The structure has been solved by both Patterson deconvolution and molecular replacement methods and refined in space group P(6)5 to an R factor of 0.225 using 2503 unique reflections greater than 3.0 sigma (F). Comparison of the molecules within the hexagonal lattice with highly refined crystal structures of other Z-DNA reveals only minor conformational differences, most notably in the pucker of the deoxyribose of the purine residues. The DNA has multiple occupancy of C:I and C:G base pairs, and C:I base pairs adopt a conformation similar to that of C:G base pairs.
About this StructureAbout this Structure
Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure at 1.5-A resolution of d(CGCICICG), an octanucleotide containing inosine, and its comparison with d(CGCG) and d(CGCGCG) structures., Kumar VD, Harrison RW, Andrews LC, Weber IT, Biochemistry. 1992 Feb 11;31(5):1541-50. PMID:1737011 Page seeded by OCA on Wed Apr 30 13:52:19 2008