Methionine gamma-lyase: Difference between revisions

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</StructureSection>
</StructureSection>
== 3D Structures of methionine γ-lyase ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*MGL
**[[1pff]] – TvMGL – ''Trichomonas vaginalis''<br />
**[[1e5f]] – TvMGL + PLP <br />
**[[1e5e]] – TvMGL + propargylglycine <br />
**[[1pg8]] – PpMGL + PLP – ''Pseudomonas putida''<br />
**[[1gc0]], [[1gc2]], [[1ukj]], [[2o7c]], [[3vk2]], [[5x2v]] – PpMGL + PLP derivative <br />
**[[5x2y]] – PpMGL (mutant) + PLP derivative <br />
**[[1y4i]], [[2rfv]], [[3mkj]], [[3jw9]], [[4oma]] – CfMGL + PLP derivative – ''Citrobacter freundii''<br />
**[[5e4z]] – CfMGL (mutant) + PLP <br />
**[[5k30]], [[6egr]] – CfMGL + PLP <br />
**[[4p7y]] – CfMGL (mutant) + PLP derivative <br />
**[[3acz]] – EhMGL + PLP derivative – ''Entamoeba histolytica''<br />
**[[5dx5]] – MGL + PLP – ''Clostridium sporogenes''<br />
*MGL complex with reaction intermediates
**[[3aej]] – EhMGL + PLP derivative + methionine + methionine-pyridoxal phosphate<br />
**[[3aem]], [[3aen]] – EhMGL + PLP derivative + methionine + butenoic acid-pyridoxal phosphate<br />
**[[3ael]] – EhMGL + methionine imine-pyridoxamine phosphate + butenoic acid-pyridoxal phosphate + methanethiol<br />
**[[3aep]] – EhMGL + butenoic acid-pyridoxal phosphate + methanethiol<br />
**[[3aeo]] – EhMGL + methionine enamine-pyridoxamine phosphate <br />
**[[5x2w]] – PpMGL + methionine intermediate<br />
**[[5x2z]] – PpMGL (mutant) + methionine intermediate<br />
**[[3vk3]] – PpMGL (mutant) + PLP derivative + methionine<br />
**[[3jwa]] – CfMGL + PLP derivative + methionine phosphinate<br />
*MGL other complexes
**[[5m3z]] – CfMGL + PLP + norleucine<br />
**[[3jwb]] – CfMGL + PLP derivative + norleucine<br />
**[[5x2x]] – PpMGL + homocysteine intermediate<br />
**[[5x30]] – PpMGL (mutant) + homocysteine intermediate<br />
**[[3vk4]] – PpMGL (mutant) + PLP derivative + homocysteine<br />
**[[4hf8]] – CfMGL (mutant) + pyridoxyl-glycine phosphate + glycine<br />
**[[5d5s]] – CfMGL (mutant) + PLP + hydroxycysteine<br />
**[[4mkj]] – CfMGL + PLP derivative + allicin<br />
**[[4mkk]] – CfMGL (mutant) + PLP derivative + allicin<br />
}}


== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 12:26, 30 October 2019

Function

Methionine γ-lyase (MGL) degrades sulfur-containing amino acids to α-keto acids, ammonia and thiols. It catalyzes the interconversion of L-methionine and water to methanethiol, ammonia and 2-oxobutanoate. MGL uses pyridoxal phosphate (PLP) as cofactor[1].

Structural highlights

MGL active site contains the cofactor PLP[2].

3D Structures of methionine γ-lyase

Methionine γ-lyase 3D structures


Methionine γ-lyase complex with PLP and sulfate (PDB code 1pg8)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Goyer A, Collakova E, Shachar-Hill Y, Hanson AD. Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway. Plant Cell Physiol. 2007 Feb;48(2):232-42. Epub 2006 Dec 13. PMID:17169919 doi:http://dx.doi.org/10.1093/pcp/pcl055
  2. ↑ Mamaeva DV, Morozova EA, Nikulin AD, Revtovich SV, Nikonov SV, Garber MB, Demidkina TV. Structure of Citrobacter freundii L-methionine gamma-lyase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jun 1;61(Pt, 6):546-9. Epub 2005 Jun 1. PMID:16511092 doi:10.1107/S1744309105015447

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Michal Harel, Joel L. Sussman, Jaime Prilusky
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