6sky: Difference between revisions
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==FAT and kinase domain of CtTel1== | |||
<StructureSection load='6sky' size='340' side='right'caption='[[6sky]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6sky]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chaetomium_thermophilum_(strain_dsm_1495_/_cbs_144.50_/_imi_039719) Chaetomium thermophilum (strain dsm 1495 / cbs 144.50 / imi 039719)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SKY FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sky OCA], [http://pdbe.org/6sky PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sky RCSB], [http://www.ebi.ac.uk/pdbsum/6sky PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sky ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/G0S4S9_CHATD G0S4S9_CHATD]] Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.[RuleBase:RU365027] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Non-specific serine/threonine protein kinase]] | |||
[[Category: Eustermann, S E]] | |||
[[Category: Hopfner, K P]] | |||
[[Category: Jansma, M]] | |||
[[Category: Kostrewa, D]] | |||
[[Category: Lammens, K]] | |||
[[Category: Alpha solenoid]] | |||
[[Category: Dimer]] | |||
[[Category: Dna damage signaling]] | |||
[[Category: Kinase]] | |||
[[Category: Nucleus]] | |||
[[Category: Pikk]] | |||
[[Category: Tranferase]] | |||
[[Category: Transferase]] | |||