6in2: Difference between revisions

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'''Unreleased structure'''


The entry 6in2 is ON HOLD  until Paper Publication
==Crystal structure of BRD1 in complex with 18-Crown-6==
 
<StructureSection load='6in2' size='340' side='right'caption='[[6in2]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
Authors: Yokoyama, T., Kosaka, Y., Matsumoto, K., Kitakami, R., Nabeshima, Y., Mizuguchi, M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6in2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IN2 FirstGlance]. <br>
Description: Crystal structure of BRD1 in complex with 18-Crown-6
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=O4B:1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE'>O4B</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6in2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6in2 OCA], [http://pdbe.org/6in2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6in2 RCSB], [http://www.ebi.ac.uk/pdbsum/6in2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6in2 ProSAT]</span></td></tr>
[[Category: Nabeshima, Y]]
</table>
[[Category: Yokoyama, T]]
== Function ==
[[http://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Kitakami, R]]
[[Category: Kitakami, R]]
[[Category: Kosaka, Y]]
[[Category: Kosaka, Y]]
[[Category: Matsumoto, K]]
[[Category: Mizuguchi, M]]
[[Category: Mizuguchi, M]]
[[Category: Matsumoto, K]]
[[Category: Nabeshima, Y]]
[[Category: Yokoyama, T]]
[[Category: Acetyl-lysine]]
[[Category: Bromodomain]]
[[Category: Transcription]]

Revision as of 11:59, 30 October 2019

Crystal structure of BRD1 in complex with 18-Crown-6Crystal structure of BRD1 in complex with 18-Crown-6

Structural highlights

6in2 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BRD1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.[1] [2]

References

  1. ↑ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 6;21(1):51-64. PMID:16387653 doi:10.1016/j.molcel.2005.12.007
  2. ↑ Qin S, Jin L, Zhang J, Liu L, Ji P, Wu M, Wu J, Shi Y. Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF). J Biol Chem. 2011 Oct 21;286(42):36944-55. doi: 10.1074/jbc.M111.244400. Epub, 2011 Aug 31. PMID:21880731 doi:http://dx.doi.org/10.1074/jbc.M111.244400

6in2, resolution 1.75Å

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OCA
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