6in0: Difference between revisions

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-'''Unreleased structure'''
-The entry 6in0 is ON HOLD  until Paper Publication
+==Crystal structure of EphA3 in complex with 18-Crown-6==
+<StructureSection load='6in0' size='340' side='right'caption='[[6in0]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-Authors: Yokoyama, T., Kosaka, Y., Matsumoto, K., Kitakami, R., Nabeshima, Y., Mizuguchi, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6in0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IN0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IN0 FirstGlance]. <br>
-Description: Crystal structure of EphA3 in complex with 18-Crown-6
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=O4B:1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE'>O4B</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-[[Category: Nabeshima, Y]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6in0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6in0 OCA], [http://pdbe.org/6in0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6in0 RCSB], [http://www.ebi.ac.uk/pdbsum/6in0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6in0 ProSAT]</span></td></tr>
-[[Category: Yokoyama, T]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/EPHA3_HUMAN EPHA3_HUMAN]] Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:[http://omim.org/entry/114500 114500]].
+== Function ==
+[[http://www.uniprot.org/uniprot/EPHA3_HUMAN EPHA3_HUMAN]] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.<ref>PMID:11870224</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Receptor protein-tyrosine kinase]]
 [[Category: Kitakami, R]]
 [[Category: Kosaka, Y]]
+[[Category: Matsumoto, K]]
 [[Category: Mizuguchi, M]]
-[[Category: Matsumoto, K]]
+[[Category: Nabeshima, Y]]
+[[Category: Yokoyama, T]]
+[[Category: Hydrolase]]
+[[Category: Tyrosine protein kinase]]