6ef5: Difference between revisions

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'''Unreleased structure'''


The entry 6ef5 is ON HOLD  until Paper Publication
==14-3-3 with peptide==
 
<StructureSection load='6ef5' size='340' side='right'caption='[[6ef5]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
Authors: Dhagat, U., Langendorf, C.G., Parker, M.W.P., Oakhill, J.S., Scott, J.W.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6ef5]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EF5 FirstGlance]. <br>
Description: 14-3-3 with peptide
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ef5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ef5 OCA], [http://pdbe.org/6ef5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ef5 RCSB], [http://www.ebi.ac.uk/pdbsum/6ef5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ef5 ProSAT]</span></td></tr>
[[Category: Langendorf, C.G]]
</table>
[[Category: Scott, J.W]]
== Function ==
[[Category: Oakhill, J.S]]
[[http://www.uniprot.org/uniprot/1433Z_HUMAN 1433Z_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.<ref>PMID:9360956</ref> <ref>PMID:14578935</ref> <ref>PMID:15071501</ref> <ref>PMID:15644438</ref> <ref>PMID:16376338</ref> 
[[Category: Parker, M.W.P]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Dhagat, U]]
[[Category: Dhagat, U]]
[[Category: Langendorf, C G]]
[[Category: Oakhill, J S]]
[[Category: Parker, M W.P]]
[[Category: Scott, J W]]
[[Category: 14-3-3]]
[[Category: Kinase]]
[[Category: Metabolic signalling protein]]
[[Category: Phosphorylation]]
[[Category: Protein-protein binding]]
[[Category: Signaling protein]]

Revision as of 11:57, 30 October 2019

14-3-3 with peptide14-3-3 with peptide

Structural highlights

6ef5 is a 8 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[1433Z_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.[1] [2] [3] [4] [5]

References

  1. ↑ Dubois T, Rommel C, Howell S, Steinhussen U, Soneji Y, Morrice N, Moelling K, Aitken A. 14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction. J Biol Chem. 1997 Nov 14;272(46):28882-8. PMID:9360956
  2. ↑ Zheng W, Zhang Z, Ganguly S, Weller JL, Klein DC, Cole PA. Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation. Nat Struct Biol. 2003 Dec;10(12):1054-7. Epub 2003 Oct 26. PMID:14578935 doi:10.1038/nsb1005
  3. ↑ Tsuruta F, Sunayama J, Mori Y, Hattori S, Shimizu S, Tsujimoto Y, Yoshioka K, Masuyama N, Gotoh Y. JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J. 2004 Apr 21;23(8):1889-99. Epub 2004 Apr 8. PMID:15071501 doi:10.1038/sj.emboj.7600194
  4. ↑ Ganguly S, Weller JL, Ho A, Chemineau P, Malpaux B, Klein DC. Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1222-7. Epub 2005 Jan 11. PMID:15644438 doi:0406871102
  5. ↑ Gu YM, Jin YH, Choi JK, Baek KH, Yeo CY, Lee KY. Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon. FEBS Lett. 2006 Jan 9;580(1):305-10. Epub 2005 Dec 19. PMID:16376338 doi:S0014-5793(05)01485-7

6ef5, resolution 2.44Å

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