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| <StructureSection load='2ooh' size='350' side='right' caption='Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry [[2ooh]])' scene='55/551208/Cv/1'> | | <StructureSection load='2ooh' size='350' side='right' caption='Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry [[2ooh]])' scene='55/551208/Cv/1'> |
| == Function == | | == Function == |
| '''Macrophage inhibitory factor''' '''Macrophage migration inhibitory factor''' (MIF) is an inflammatory cytokine. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens<ref>PMID:11032394</ref>. | | '''Macrophage inhibitory factor''' or '''Macrophage migration inhibitory factor''' (MIF) is an inflammatory cytokine. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens<ref>PMID:11032394</ref>. |
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| == Relevance == | | == Relevance == |
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| </StructureSection> | | </StructureSection> |
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| ==3D structures of macrophage inhibitory factor==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *macrophage inhibitory factor
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| **[[1fim]], [[1gif]], [[1gd0]], [[3djh]] – hMIF – human<BR />
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| **[[1cgq]], [[1p1g]], [[4etg]], [[4eui]], [[4evg]], [[4grn]], [[4gro]], [[4grp]], [[4grq]], [[4grr]], [[4gru]], [[6bg6]], [[6bg7]], [[5v73]], [[5v70]], [[5uzy]], [[5umk]], [[5umj]], [[5hvv]], [[5hvt]], [[5hvs]], [[5eiz]], [[5bsj]], [[5bsi]], [[5bsc]], [[5bs9]], [[4xx8]], [[4xx7]], [[4tru]], [[4trf]], [[4pkz]], [[4pkk]] – hMIF (mutant) <BR />
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| **[[6ice]] – MIF – hamster<BR />
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| **[[1mif]] – MIF (mutant) – rat<BR />
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| **[[1mff]] – mMIF (mutant) – mouse<BR />
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| **[[1hfo]] – MIF – ''Trichinella spiralis'' <BR />
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| **[[1uiz]] – MIF – ''Xenopus laevis'' <BR />
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| **[[2wkb]], [[2wkf]] – MIF – ''Plasmodium berghei'' <BR />
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| **[[3t5s]] – MIF – ''Giardia lamblia''<BR />
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| **[[4gum]] – MIF (mutant) – rhesus monkey<BR />
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| **[[4dh4]] – MIF – ''Toxoplasma gondii'' <BR />
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| *MIF complexes
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| **[[1ca7]] – hMIF + hydroxyphenylpyruvate<BR />
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| **[[3ijj]] – hMIF + hydroxyphenylpyruvate + inhibitor<BR />
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| **[[1gcz]], [[1ljt]], [[2ooh]], [[2oow]], [[2ooz]], [[3b9s]], [[3jsf]], [[3jsg]], [[3jtu]], [[3l5p]], [[3l5r]], [[3l5s]], [[3l5t]], [[3l5u]], [[3l5v]], [[3ijg]], [[4f2k]], [[3smb]], [[3smc]], [[3wnr]], [[3wns]], [[3wnt]], [[4osf]], [[4p01]], [[4k9g]], [[4oyq]], [[4p0h]], [[4wr8]], [[4wrb]], [[6b1c]], [[6b1k]], [[6b2c]], [[6cb5]], [[6bcf]], [[6cbg]], [[6cbh]], [[6fve]], [[6fvh]], [[5xej]], [[5j7q]], [[5j7p]], [[5b4o]], [[4z1u]], [[4z1t]], [[4z15]], [[4plu]], [[6cbf]] – hMIF + inhibitor <BR />
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| **[[3dji]] – hMIF + tylenol<BR />
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| **[[3ce4]] – hMIF + PMSF<BR />
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| **[[3hof]] – hMIF + cafeic acid<BR />
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| **[[3u18]] – hMIF + Chicago sky blue<BR />
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| **[[1mfi]], [[2gdg]] – mMIF + inhibitor <BR />
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| **[[3rf4]], [[3rf5]] – MIF + inhibitor – ''Ancylostoma ceylanicum''<br />
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| **[[4p7m]], [[4p7s]] – MIF + inhibitor – ''Plasmodium falciparum''<BR />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |