Macrophage inhibitory factor: Difference between revisions
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<StructureSection load='2ooh' size='350' side='right' caption='Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry [[2ooh]])' scene='55/551208/Cv/1'> | <StructureSection load='2ooh' size='350' side='right' caption='Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry [[2ooh]])' scene='55/551208/Cv/1'> | ||
== Function == | == Function == | ||
'''Macrophage inhibitory factor''' (MIF) is an inflammatory cytokine. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens<ref>PMID:11032394</ref>. | '''Macrophage inhibitory factor''' '''Macrophage migration inhibitory factor''' (MIF) is an inflammatory cytokine. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens<ref>PMID:11032394</ref>. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
MIF contains two different catalytic sites. A phenylpyruvate tautomerase site is located in the N terminal. A <scene name='55/551208/Cv/5'>disulfide reductase site is located in the tetrapeptide Cys-Ala-Leu-Cys in position 57-60</scene>. The <scene name='55/551208/Cv/6'>inhibitor binds to the pro-inflammatory tautomerase site</scene><ref>PMID:17526494</ref>. Water molecules shown as red spheres. | MIF contains two different catalytic sites. A phenylpyruvate tautomerase site is located in the N terminal. A <scene name='55/551208/Cv/5'>disulfide reductase site is located in the tetrapeptide Cys-Ala-Leu-Cys in position 57-60</scene>. The <scene name='55/551208/Cv/6'>inhibitor binds to the pro-inflammatory tautomerase site</scene><ref>PMID:17526494</ref>. Water molecules shown as red spheres. | ||
==3D structures of macrophage inhibitory factor== | |||
[[Macrophage inhibitory factor 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
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*macrophage inhibitory factor | *macrophage inhibitory factor | ||
**[[1fim]], [[1gif]], [[1gd0]], [[3djh]] – hMIF – human<BR /> | **[[1fim]], [[1gif]], [[1gd0]], [[3djh]] – hMIF – human<BR /> | ||
**[[1cgq]], [[1p1g]], [[4etg]], [[4eui]], [[4evg]], [[4grn]], [[4gro]], [[4grp]], [[4grq]], [[4grr]], [[4gru]], [[6bg6]], [[6bg7]], [[5v73]], [[5v70]], [[5uzy]], [[5umk]], [[5umj]], [[5hvv]], [[5hvt]], [[5hvs]], [[5eiz]], [[5bsj]], [[5bsi]], [[5bsc]], [[5bs9]], [[4xx8]], [[4xx7]], [[4tru]], [[4trf]], [[4pkz]], [[4pkk]] – hMIF (mutant) <BR /> | **[[1cgq]], [[1p1g]], [[4etg]], [[4eui]], [[4evg]], [[4grn]], [[4gro]], [[4grp]], [[4grq]], [[4grr]], [[4gru]], [[6bg6]], [[6bg7]], [[5v73]], [[5v70]], [[5uzy]], [[5umk]], [[5umj]], [[5hvv]], [[5hvt]], [[5hvs]], [[5eiz]], [[5bsj]], [[5bsi]], [[5bsc]], [[5bs9]], [[4xx8]], [[4xx7]], [[4tru]], [[4trf]], [[4pkz]], [[4pkk]] – hMIF (mutant) <BR /> | ||
**[[6ice]] – MIF – hamster<BR /> | |||
**[[1mif]] – MIF (mutant) – rat<BR /> | |||
**[[1mff]] – mMIF (mutant) – mouse<BR /> | **[[1mff]] – mMIF (mutant) – mouse<BR /> | ||
**[[1hfo]] – MIF – ''Trichinella spiralis'' <BR /> | **[[1hfo]] – MIF – ''Trichinella spiralis'' <BR /> | ||
| Line 30: | Line 35: | ||
*MIF complexes | *MIF complexes | ||
**[[1ca7]] – hMIF + hydroxyphenylpyruvate<BR /> | **[[1ca7]] – hMIF + hydroxyphenylpyruvate<BR /> | ||
**[[3ijj]] – hMIF + hydroxyphenylpyruvate + inhibitor<BR /> | **[[3ijj]] – hMIF + hydroxyphenylpyruvate + inhibitor<BR /> | ||
**[[1gcz]], [[1ljt]], [[2ooh]], [[2oow]], [[2ooz]], [[3b9s]], [[3jsf]], [[3jsg]], [[3jtu]], [[3l5p]], [[3l5r]], [[3l5s]], [[3l5t]], [[3l5u]], [[3l5v]], [[3ijg]], [[4f2k]], [[3smb]], [[3smc]], [[3wnr]], [[3wns]], [[3wnt]], [[4osf]], [[4p01]], [[4k9g]], [[4oyq]], [[4p0h]], [[4wr8]], [[4wrb]], [[6b1c]], [[6b1k]], [[6b2c]], [[6cb5]], [[6bcf]], [[6cbg]], [[6cbh]], [[6fve]], [[6fvh]], [[5xej]], [[5j7q]], [[5j7p]], [[5b4o]], [[4z1u]], [[4z1t]], [[4z15]], [[4plu]] – hMIF + inhibitor <BR /> | **[[1gcz]], [[1ljt]], [[2ooh]], [[2oow]], [[2ooz]], [[3b9s]], [[3jsf]], [[3jsg]], [[3jtu]], [[3l5p]], [[3l5r]], [[3l5s]], [[3l5t]], [[3l5u]], [[3l5v]], [[3ijg]], [[4f2k]], [[3smb]], [[3smc]], [[3wnr]], [[3wns]], [[3wnt]], [[4osf]], [[4p01]], [[4k9g]], [[4oyq]], [[4p0h]], [[4wr8]], [[4wrb]], [[6b1c]], [[6b1k]], [[6b2c]], [[6cb5]], [[6bcf]], [[6cbg]], [[6cbh]], [[6fve]], [[6fvh]], [[5xej]], [[5j7q]], [[5j7p]], [[5b4o]], [[4z1u]], [[4z1t]], [[4z15]], [[4plu]], [[6cbf]] – hMIF + inhibitor <BR /> | ||
**[[3dji]] – hMIF + tylenol<BR /> | **[[3dji]] – hMIF + tylenol<BR /> | ||
**[[3ce4]] – hMIF + PMSF<BR /> | **[[3ce4]] – hMIF + PMSF<BR /> | ||
**[[3hof]] – hMIF + cafeic acid<BR /> | **[[3hof]] – hMIF + cafeic acid<BR /> | ||
**[[3u18]] – hMIF + Chicago sky blue<BR /> | **[[3u18]] – hMIF + Chicago sky blue<BR /> | ||
**[[1mfi]], [[2gdg]] – mMIF + inhibitor <BR /> | |||
**[[3rf4]], [[3rf5]] – MIF + inhibitor – ''Ancylostoma ceylanicum''<br /> | **[[3rf4]], [[3rf5]] – MIF + inhibitor – ''Ancylostoma ceylanicum''<br /> | ||
**[[4p7m]], [[4p7s]] – MIF + inhibitor – ''Plasmodium falciparum''<BR /> | **[[4p7m]], [[4p7s]] – MIF + inhibitor – ''Plasmodium falciparum''<BR /> | ||
Revision as of 12:10, 24 October 2019
FunctionMacrophage inhibitory factor Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens[1]. RelevanceMIF plays a role in various solid and hematologic tumors[2]. MIF is overexpressed in various tumors and is suggested to be the molecular link between chronic inflammation and cancer. MIF has a role in skin inflammation, immune response, disease, tumorigenesis and wound healing[3]. MIF has a role in Alzheimer disease and its inhibition may prevent the disease onset[4]. Structural highlightsMIF contains two different catalytic sites. A phenylpyruvate tautomerase site is located in the N terminal. A . The [5]. Water molecules shown as red spheres. 3D structures of macrophage inhibitory factorMacrophage inhibitory factor 3D structures
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3D structures of macrophage inhibitory factor3D structures of macrophage inhibitory factor
Updated on 24-October-2019
ReferencesReferences
- ↑ Nishihira J. Macrophage migration inhibitory factor (MIF): its essential role in the immune system and cell growth. J Interferon Cytokine Res. 2000 Sep;20(9):751-62. PMID:11032394 doi:http://dx.doi.org/10.1089/10799900050151012
- ↑ Bach JP, Deuster O, Balzer-Geldsetzer M, Meyer B, Dodel R, Bacher M. The role of macrophage inhibitory factor in tumorigenesis and central nervous system tumors. Cancer. 2009 May 15;115(10):2031-40. doi: 10.1002/cncr.24245. PMID:19326434 doi:http://dx.doi.org/10.1002/cncr.24245
- ↑ Shimizu T. Role of macrophage migration inhibitory factor (MIF) in the skin. J Dermatol Sci. 2005 Feb;37(2):65-73. PMID:15659324 doi:http://dx.doi.org/10.1016/j.jdermsci.2004.08.007
- ↑ Bacher M, Deuster O, Aljabari B, Egensperger R, Neff F, Jessen F, Popp J, Noelker C, Reese JP, Al-Abed Y, Dodel R. The role of macrophage migration inhibitory factor in Alzheimer's disease. Mol Med. 2010 Mar;16(3-4):116-21. doi: 10.2119/molmed.2009.00123. Epub 2010 Feb, 28. PMID:20200619 doi:http://dx.doi.org/10.2119/molmed.2009.00123
- ↑ Crichlow GV, Cheng KF, Dabideen D, Ochani M, Aljabari B, Pavlov VA, Miller EJ, Lolis E, Al-Abed Y. Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J Biol Chem. 2007 Aug 10;282(32):23089-95. Epub 2007 May 25. PMID:17526494 doi:http://dx.doi.org/10.1074/jbc.M701825200