6fq5: Difference between revisions
m Protected "6fq5" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==Class 1 : canonical nucleosome== | ==Class 1 : canonical nucleosome== | ||
<StructureSection load='6fq5' size='340' side='right' caption='[[6fq5]], [[Resolution|resolution]] 3.80Å' scene=''> | <StructureSection load='6fq5' size='340' side='right'caption='[[6fq5]], [[Resolution|resolution]] 3.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6fq5]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FQ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FQ5 FirstGlance]. <br> | <table><tr><td colspan='2'>[[6fq5]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FQ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FQ5 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fq5 OCA], [http://pdbe.org/6fq5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fq5 RCSB], [http://www.ebi.ac.uk/pdbsum/6fq5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fq5 ProSAT]</span></td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hist1h2aj, LOC494591 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog]), XELAEV_18032686mg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fq5 OCA], [http://pdbe.org/6fq5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fq5 RCSB], [http://www.ebi.ac.uk/pdbsum/6fq5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fq5 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
| Line 17: | Line 18: | ||
</div> | </div> | ||
<div class="pdbe-citations 6fq5" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6fq5" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Histone 3D structures|Histone 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: African clawed frog]] | |||
[[Category: Large Structures]] | |||
[[Category: Bilokapic, S]] | [[Category: Bilokapic, S]] | ||
[[Category: Halic, M]] | [[Category: Halic, M]] | ||
Revision as of 10:53, 23 October 2019
Class 1 : canonical nucleosomeClass 1 : canonical nucleosome
Structural highlights
Function[H4_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Publication Abstract from PubMedNucleosomes, the basic unit of chromatin, package and regulate expression of eukaryotic genomes. Nucleosomes are highly dynamic and are remodeled with the help of ATP-dependent remodeling factors. Yet, the mechanism of DNA translocation around the histone octamer is poorly understood. In this study, we present several nucleosome structures showing histone proteins and DNA in different organizational states. We observe that the histone octamer undergoes conformational changes that distort the overall nucleosome structure. As such, rearrangements in the histone core alpha-helices and DNA induce strain that distorts and moves DNA at SHL 2. Distortion of the nucleosome structure detaches histone alpha-helices from the DNA, leading to their rearrangement and DNA translocation. Biochemical assays show that cross-linked histone octamers are immobilized on DNA, indicating that structural changes in the octamer move DNA. This intrinsic plasticity of the nucleosome is exploited by chromatin remodelers and might be used by other chromatin machineries. Structural rearrangements of the histone octamer translocate DNA.,Bilokapic S, Strauss M, Halic M Nat Commun. 2018 Apr 6;9(1):1330. doi: 10.1038/s41467-018-03677-z. PMID:29626188[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
|
| ||||||||||||||||